Внебольничные MRSA — новая проблема антибиотикорезистентности

Клиническая Микробиология и Антимикробная Химиотерапия. 2005; 7(1):32-46

​ Страчунский Л.С., Белькова Ю.А., Дехнич А.В.
метициллинорезистентный Staphylococcus aureus MRSA внебольничные инфекции антибиотикорезистентность
Раздел
Болезни и возбудители
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2005; 7(1):32-46

Аннотация

Staphylococcus aureus остаётся одним из важнейших возбудителей инфекций человека. Особое беспокойство вызывает появление в последние годы инфекций, вызванных метициллинорезистентными S.aureus (MRSA) не только нозокомиального, но и внебольничного происхождения. Представлены основные отличия внебольничных MRSA от нозокомиальных MRSA, приведены данные об эпидемиологии и профилактике распространения внебольничных MRSA. Особое внимание уделено вопросам диагностики и лечения инфекций, вызванных внебольничными MRSA.

  • 1. Centers for Disease Control and Prevention. Four pedi- atric deaths from community-acquired methicillin-resistant Staphylococcus aureus - Minnesota and North Dakota, 1997 1999. JAMA 1999; 282:1123-5.
  • 2. Chambers H. The Changing Epidemiology of Staphylococcus aureus? Emerg Inf Dis 2001; 7:178-82.
  • 3. Barber M. Methicillin-resistant staphylococci. J Clin Pathol 1961; 14:385-93.
  • 4. Centers for Disease Control and Prevention: reduced susceptibility of Staphylococcus aureus to vancomycin. Japan, 1997. MMWR 1997; 46:624-6.
  • 5. Дехнич А.В., Эйдельштейн И.А., Нарезкина А.Д., Афиногенов Г.Е., Ахметова Л.И., Боронина Л.Г. и др. Эпидемиология антибиотикорезистентности нозокомиальных штаммов Staphylococcus aureus в России: результаты многоцентрового исследования. Клиническая Микробиология и Антимикробная Химиотерапия 2002; 4:325-36.
  • 6. Moreillon P., Que Y.A., Glauser M.P. Staphylococcus aureus. In: Mandell G.L., Bennett J.E., Raphael D., editors. Principles and practice of infectious diseases. 6th ed. Philadelphia: Elsevier Churchill Livingston; 2005. p. 2321-52.
  • 7. Sanford M.D., Widmer A.F., Bale M.J., Jones R.N., Wenzel R.P. Efficient detection and long-term persistance of the carriage of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 1994; 19:1123-8.
  • 8. Turnidge J.D., Bell J.M. Prevalence of non-multiresistant oxacillin-resistant Staphylococcus aureus in the SENTRY Asia Pacific region, 1998-2003. Proceedings of the 44th ICAAC; 2004. Washington: ASM Press; 2004. Abstract C2-2005.
  • 9. Salgado C.D., Farr B.M., Calfee D.P. Community- acquired methicillin-resistant Staphylococcus aureus: A meta-analysis of prevalence and risk factors. Clin Infect Dis 2003; 36:131-9.
  • 10. Moellering R.C. Community-acquired methicillin-resistant Staphylococcus aureus: no longer confined to the inpatient arena. Infect Dis Special Edition 2003; 6:63-7.
  • 11. Cookson B.D. Methicillin-resistant Staphylococcus aureus in the community: new battlefronts, or are the battles lost? Infect Control Hosp Epidemiol 2000; 21:398- 403.
  • 12. Herold B.C., Immergluck L.C., Maranan M.C., Lauderdale D.S., Gaskin R.E., Boyle-Vavra S., et al. Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. JAMA 1998; 279:593-8.
  • 13. Charlebois E.D., Perdreau-Remington F., Kreiswirth B., Bangsberg D.R., Ciccarone D., Diep B.A., et al. Origins of community strains of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 2004; 39:47-54.
  • 14. Adcock P.M., Pastor P., Medley F., Patterson J.E., Murphy T.V. Methicillin-resistant Staphylococcus aureus in two child care centers. J Infect Dis 1998; 178:577-80.
  • 15. Hussain F.M., Boile-Vavra S., Daum R.S. Community-acquired methicillin-resistant Staphylococcus aureus col- onization in healthy children attending an outpatient pediatric clinic. Pediatr Infect Dis J 2001; 20:763-7.
  • 16. Lindenmayer J.M., Schoenfeld S., O’Grady R., Carney J.K. Methicillin-resistant Staphylococcus aureus in a high school wrestling team and the surrounding community. Arch Intern Med 1998; 158:895-9.
  • 17. Fey P.D., Said-Salim B., Rupp M. E., Hinrichs S.H., Boxrud D.J., Davis C.C., et al. Comparative molecular analysis of community- or hospital-acquired methicillin- resistant Staphylococcus aureus. Antimicrob Agents Chemother 2003; 47: 96-203.
  • 18. Daum R.S., Ito T., Hiramatsu K., Hussain F., Mon- gkolrattanothai K., Jamklang M., et al. A novel methicillin-resistance cassette in community-acquired methi- cillin-resistant Staphylococcus aureus isolates of diverse genetic backgrounds. J Infect Dis 2002; 186:1344-7.
  • 19. Okuma K., Iwakawa K., Turnidge J.D., Grubb W.B., Bell J.M., O’Brien F.G., et al. Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J Clin Microbiol 2002; 40:4289-94.
  • 20. Boutiba-Ben Boubaker I., Ben Abbes R., Ben Abdallah H., Mamlouk K., Mahjoubi F., Kammoun A., et al. Evaluation of a cefoxitin disk diffusion test for the routine detection of methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect 2004; 10:762-5.
  • 21. Wu S., Piscitelli C., deLancastre H., Tomasz A. Tracking the evolutionary origin of the methicillin resistance gene: cloning and sequencing of a homologue of mecA from a methicillin susceptible strain of Staphylococcus sciuri. Microb Drug Resist 1996;2:435–41.
  • 22. Chambers H. F. Tracking the spread of CMRSA. APUA Newsletter 2003; 21(2):1-5.
  • 23. Palavecino E. Community-acquired methicillin-resistant Staphylococcus aureus infections. Clin Lab Med 2004; 24:403-18.
  • 24. Kreiswirth B., Kornblum J., Arbeit R.D., Eisner W., Mas- low J.N., McGeer A., et al. Evidence for a clonal origin of methicillin resistance in Staphylococcus aureus. Science 1993; 259:227-30.
  • 25. Hiramatsu K. Molecular evolution of MRSA. Microbiol Immunol 1995; 39:531-43.
  • 26. Enright M.C., Robinson D.A., Randle G., Feil E.J., Grundmann H., Spratt B.G. The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA). Proc Natl Acad Sci USA 2002; 99:7687-92.
  • 27. Hiramatsu K., Longzhu C., Kuroda M., Ito T. The emer- gence and evolution of methicillin-resistant Staphylococcus aureus. Trends Microbiol 2001; 9:486-93.
  • 28. Katayama Y., Ito T., Hiramatsu K. A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 2000; 44:1549-55.
  • 29. Lina G., Pijmont Y., Godail-Gamot F., Bes M., Peter M., Gauduchon V., et al. Involvement of Panton-Valentine leukocidin – producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis 1999; 29:1128-32.
  • 30. Prevost G., Couppie P., Prevost P., Gayet S., Petiau P., Cribier B., et al. Epidemiological data on Staphylococcus aureus strains producing synergohymenotropic toxins. J Med Microbiol 1995; 42:237-45.
  • 31. Groom A.V., Wolsey D.H., Naimi T.S., Smith K., John- son S., Boxrud D. Community-acquired methicillin- resistant Staphylococcus aureus in a rural American Indian community. JAMA 2001; 286:1201-5.
  • 32. Naimi T.S., LeDell K.H., Boxrud D.J., Groom A.V., Steward C.D., Johnson S.K., et al. Epidemiology and clonality of community-acquired methicillin-resistant Staphylococcus aureus in Minnesota, 1996-1998. Clin Infect Dis 2001; 33:990-6.
  • 33. National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Susceptibility Testing; Fourteenth Informational Supplement. NCCLS document M100-S14. 2004; 24(1):109.
  • 34. Mulder J.G. Comparison of disk diffusion, the E test, and detection of mecA for determination of methicillin resis- tance in coagulase-negative staphylococci. Eur J Clin Microbiol Infect Dis 1996; 15:567-73.
  • 35. Определение чувствительности микроорганизмов к антибактериальнм препаратам. Методические указания МУК 4.2.1890-04. Минздрав России.
  • 36. Vannuffel P., Laterre P.F., Bouyer M., Gigi J., Vandercam B., Reynaert M., et al. Rapid and specific molecular identification of methicillin-resistant Staphylococcus aureus in endotracheal aspirates from mechanically ventilated patients. J Clin Microbiol 1998; 36:2366-8.
  • 37. Fang H., Hedin G. Rapid screening and identification of methicillin-resistant Staphylococcus aureus from clinical samples by selective-broth and real-time PCR assay. J Clin Microbiol 2003; 41:2894-9.
  • 38. Grisold A.J., Leitner E., Muhlbauer G., Marth E., Kes- sler H.H. Detection of methicillin-resistant Staphylococcus aureus and simultaneous confirmation by auto- mated nucleic acid extraction and real-time PCR. J Clin Microbiol 2002; 40: 2392-7.
  • 39. Soll D.R., Lockhart S.R., Pujol C. Laboratory procedures for the epidemiologic analysis of microorganisms. In: Murray P.M., Baron E.J., Pfaller M.A., Tenover F.C., Yolken R.H., eds. Manual of clinical microbiology. 8th ed. Washington, DC: ASM Press, 2003.
  • 40. Weller T.M.A. Methicillin-resistant Staphylococcus aureus typing methods: which should be the internation- al standard? J Hosp Infect 2000; 44:160-72.
  • 41. Шагинян И.А. Идентификация и типирование патогенных бактерий: современные подходы. Вестн РАМН 2000; 1:22-8.
  • 42. Bannerman T.L., Hancock G.A., Tenover F.C., Mil- ler J.M. Pulsed-field gel electrophoresis as a replacement for bacteriophage typing of Staphylococcus aureus. J Clin Microbiol 1995; 33:551-5.
  • 43. Saulnier P., Bourneix C., Prevost G., Andremont A. Random amplified polymorphic DNA assay is less dis- criminatory than pulsed-field gel electrophoresis for typ- ing strains of methicillin-resistant Staphylococcus aureus. J Clin Microbiol 1993; 31:982-5.
  • 44. Trindade P.A., McCulloch J.A., Oliveira G.A., Mamizuka E.M. Molecular Techniques for MRSA Typing: Current Issues and Perspectives. Braz J Infect Dis 2003; 7:32-43.
  • 45. Kallen A.J., Driscoll T.J., Thornton S., Olson P.E., Wallace M.R. Increase in community-acquired methi- cillin-resistant Staphylococcus aureus at a naval medical center. Infect Control Hosp Epidemiol 2000; 21:223-6.
  • 46. Groom A.V., Wolsey D.H., Naimi T.S., Smith K., John- son S., Boxrud D., et al. Community-acquired methi- cillin-resistant Staphylococcus aureus in a rural American Indian community. JAMA 2001; 286:1201 5.
  • 47. Siberry G.K., Tekle T., Carroll K., Dick J. Failure of Clindamycin treatment of methicillin-resistatnt Staphylococcus aureus expressing inducible clindamycin resis- tance in vitro. Clin Infect Dis 2003; 37:1257-60.
  • 48. Baum S.E., Morris J.T., Dooley D.P., Watson R. Methi- cillin-resistant Staphylococcus aureus in an adult military beneficiary population lacking risk factors: susceptibility to orally available agents. Mil Med 2003; 168:126-30.
  • 49. Kang S.L., Rybak M.J., McGrath B.J., Kaatz G.W., Seo S.M. Pharmacokinetics of levofloxacin, ofloxacin and ciprofloxacin alone and in combination with rifampicin against methicillin-susceptible and – resistant Staphylococcus aureus in an in vitro infection model. Antimicrob Agents Chemother 1994; 38:2702-9.
  • 50. Memikoglu O., Bayar B., Kurt O., Cokca F. In vitro sus- ceptibility of methicillin-resistant Staphylococcus aureus to fusidic acid and trimethoprim-sulfamethoxazole. Mikrobiyol Bul 2002; 36:141-5.
  • 51. Doern G.V., Jones R.N., Pfaller M., Kugler K., Beach M.L. and The SENTRY study group. Bacterial pathogens isolated from patients with skin and soft tissue infections: Frequency of occurrence and antimicrobial susceptibility patterns from SENTRY antimicrobial sur- veillance program (USA and Canada, 1997). Diagn Microbiol Infect Dis 1999;34:65-72.
  • 52. Turnidge J., Collignon P. Resistance to fusidic acid. Int J Antimicrob Agents 1999; 12 (Suppl 2):35-44.
  • 53. Jones M.E., Visser M.R., Klootwijk M., Heisig P., Verhoef J., Schmitz F.J. Comparative activities of cli- nafloxacin, grepafloxacin, levofloxacin, moxifloxacin, ofloxacin, sparfloxacin, and trovafloxacin and non- quinolones linozelid, quinupristin-dalfopristin, gentam- icin, and vancomycin against clinical isolates of ciprofloxacin-resistant and -susceptible Staphylococcus aureus strains. Antimicrob Agents Chemother 1999; 43:421-3.
  • 54. Schmitz F.-J., Fluit A.C., Hafner D., Beeck A., Perdi- kouli M., Boos M. Development of resistance to ciprofloxacin, rifampin and mupirocin in methicillin-sus- ceptible and –resistant Staphylococcus aureus isolates. Antimicrob Agent Chemother 2000; 44:3229-31.
  • 55. Levine D.P., Fromm B.S., Reddy B.R. Slow response to vancomycin or vancomycin plus rifampin in methicillin- resistant Staphylococcus aureus endocarditis. Ann Intern Med 1991; 115:674-80.
  • 56. Reduced susceptibility of Staphylococcus aureus to van- comycin – Japan, 1996. Morb Mortal Wkly Rep 1997; 46:624-6.
  • 57. Presterl E., Mueller-Uri P., Grisold A., Georgopoulus A., Graninger W. Ciprofloxacin- and methicillin-resistant Staphylococcus aureus susceptible to moxifloxacin, lev- ofloxacin, teicoplanin, vancomycin and linezolid. Eur Clin Microbiol Infect Dis 2001; 20:486-9.
  • 58. Henwood C.J., Livermore D.M., Johnson A.P., James D., Warner M., Gardiner A. Susceptibility of gram-positive cocci from 25 UK hospitals to antimicrobial agents including linezolid. The Linezolid Study Group. J Antimicrob Chemother 2000; 46:931-40.
  • 59. Сookson B.D. The emergence of mupirocin resistance: a challenge to infection control and antibiotic prescribing practice. J Antimicrob Chemother 1998; 41:11-8.
  • 60. El Mofty M., Harvey S.G., Gibson J.R., Calthrop J.G., Marks P. Trimethoprim-polymyxin B sulphate cream compared with fusidic acid cream in the treatment of superficial bacterial infection of the skin. J Int Med Res 1990; 18:89-93.
  • 61. Fritsche T.R., Kirby J., Jones R.N. Activity of tigecycline tested against 3,498 Staphylococcus aureus: an assessment versus community-acquired ORSA. Proceedings of the 44th ICAAC. USA, Washington, DC. 2004. Abstract C2- 2000.
  • 62. Anstead G.M., Owens A.D. Recent advances in the treat- ment of infections due to resistant Staphylococcus aureus. Curr Opin Infect Dis 2004; 17:549-55.
  • 63. King A., Phillips I., Kaniga K. Comparative in vitro activity of telavancin (TD-6424), a rapidly bactericidal, concentration-dependent anti-infective with multiple mechanisms of action against Gram-positive bacteria. J Antimicrob Chemother. 2004; 53:797-803.
  • 64. Petersen P.J., Wang T.Z., Dushin R.G., Bradford P.A. Comparative in vitro activities of AC98-6446, a novel semisynthetic glycopeptide derivative of the natural product mannopeptimycin alpha, and other antimicrobial agents against gram-positive clinical isolates. Antimicrob Agents Chemother 2004; 48:739-46.
  • 65. Deshpande L.M., Jones R.N. Bactericidal activity and synergy studies of BAL9141, a novel pyrrolidinone-3-yli- dene cephem, tested against streptococci, enterococci and methicillin-resistant staphylococci. Clin Microbiol Infect 2003; 9:1120-4.
  • 66. Keam S.J., Perry C.M. Prulifloxacin. Drugs 2004; 64:2221-34.
  • 67. Almer L.S., Hoffrage J.B., Keller E.L., Flamm R.K.,Shortridge V.D. In vitro and bactericidal activities of ABT-492, a novel fluoroquinolone, against Gram-posi- tive and Gram-negative organisms. Antimicrob Agents Chemother 2004; 48:2771-7.
  • 68. Otani T., Tanaka M., Ito E., Kurosaka Y., Murakami Y., Onodera K., Akasaka T., Sato K. In vitro and in vivo antibacterial activities of DK-507k, a novel fluoro- quinolone. Antimicrob Agents Chemother 2003; 47:3750-9.
  • 69. Tanaka M., Yamazaki E., Chiba M., Yoshihara K., Akasaka T., Takemura M., Sato K. In vitro antibacterial activities of DQ-113, a potent quinolone, against clinical isolates. Antimicrob Agents Chemother 2002; 46:904-8.
  • 70. Jacobs M.R., Bajaksouzian S., Windau A., Appelba- um P.C., Patel M.V., Gupte S.V., et al. In vitro activity of the new quinolone WCK 771 against staphylococci. Antimicrob Agents Chemother 2004; 48:3338-42.
  • 71. Howe R.A., Wootton M., Noel A.R., Bowker K.E., Walsh T.R., MacGowan A.P. Activity of AZD2563, a novel oxazolidinone, against Staphylococcus aureus strains with reduced susceptibility to vancomycin or linezolid. Antimicrob Agents Chemother 2003; 47:3651-2.
  • 72. Ednie L.M., Rattan A., Jacobs M.R., Appelbaum P.C. Antianaerobe activity of RBX 7644 (ranbezolid), a new oxazolidinone, compared with those of eight other agents. Antimicrob Agents Chemother 2003; 47:1143-7.
  • 73. Yong D., Yum J.H., Lee K., Chong Y., Choi S.H., Rhee J.K. In vitro activities of DA-7867, a novel oxazolidinone, against recent clinical isolates of aerobic and anaerobic bacteria. Antimicrob Agents Chemother 2004; 48:352-7.
  • 74. Lofland D., Difuntorum S., Waller A., Clements J.M., Weaver M.K., Karlowsky J.A., Johnson K. In vitro anti- bacterial activity of the peptide deformylase inhibitor BB-83698. J Antimicrob Chemother 2004; 53:664-8.
  • 75. Centers for Disease Control and Prevention. Community-associated MRSA: Frequently asked ques- tions. CDC Web site. Available from: www.cdgov/nci-dod/hip/ARESIST/mrsa_comm_faq.htm
Просмотров
0 Аннотация
0 PDF
0 Цитирования
Поделились