Перспективы лечения вирусного гепатита В

Клиническая Микробиология и Антимикробная Химиотерапия. 2000; 2(3):4-18

​ Де Клерк Э.
вирусный гепатит B противовирусная терапия
Раздел
Болезни и возбудители
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2000; 2(3):4-18

Аннотация

Переведена и печатается с согласия автора и редакции журнала “International Journal of Antimicrobial Agents” 1999;12⁄2:81-97.

В настоящее время в мире инфицированы вирусом гепатита В (HBV) 350 млн человек. Несмотря на существование вакцины, HBV остается одним из важнейших вирусов, вызывающих заболевания у человека. a Интерферон является единственным препаратом, одобренным во всем мире для лечения хронического гепатита В. Однако терапия интерфероном нередко приводит к развитию нежелательных лекарственных реакций, а результаты лечения, как правило, оказываются неудовлетворительными. Основное направление в развитии новых препаратов для терапии вирусного гепатита В направлено на подавление специфической ДНК-полимеразы HBV. Проводится оценка возможного использования для лечения больных аналогов нуклеозидов (и нуклеотидов), эффективность которых при лечении других вирусных инфекций уже доказана. Являвшиеся первоначально случайными находками при поиске эффективных анти-HSV и анти-ВИЧ агентов такие препараты, как фамцикловир (пенцикловир), BMS-200475 (энтекавир), ламивудин (3ТС), (-)FTC, L(-)Fd4C, L-FMAU, DAPD (DXG), bis(POM)-PMEA и bis(POC)-PMPA, в настоящее время являются многообещающими средствами терапии вирусного гепатита B. Можно утверждать, что будущее химиотерапии больных вирусным гепатитом B принадлежит использованию комбинаций лекарственных средств.

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