Аннотация
Начиная с 1867 г., когда Джозеф Листер впервые использовал местные аппликации карболовой кислоты при лечении открытого перелома кости, антисептики получили широкое распространение в клинической практике. При этом в отличие от препаратов для системного применения их редко изучали тщательно. Рост интереса к антимикробным препаратам для местного применения был вызван разработкой и внедрением в практику нового антибиотика – мупироцина.
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