Streptococcus pneumoniae

New Approaches to the Optimization of Antimicrobial Therapy of Respiratory Tract Infections Using Pharmacokinetic and Pharmacodynamic Parameters

Clinical Microbiology and Antimicrobial Chemotherapy. 2004; 6(1):22-31

To understand the relationship between drug dose and efficacy, pharmacokinetic (PK) and pharmacodynamic (PD) characteristics need to be integrated. There are two patterns of antimicrobial activity: time-dependent killing and concentration-dependent …

Practice Guidelines on Antimicrobial Therapy of Sinusitis

Clinical Microbiology and Antimicrobial Chemotherapy. 2003; 5(2):167-174

This paper presents data on epidemiology and etiology of sinusitis in Russia as well as antimicrobial susceptibility patterns of most likely pathogens, causing different forms of the disease. Choice of antimicrobials for treatment of different types …

Antimicrobial Resistance of Streptococcus Pneumoniae in Different Regions of Russia: Results of Prospective Multicentre Study (phase А of project PeHAS-I)

Clinical Microbiology and Antimicrobial Chemotherapy. 2002; 4(3):267-277

Objective. To determine the structure of antimicrobial resistance of clinical isolates of pneumococci in different regions of Russia. Materials and Methods. A total of 210 Streptococcus pneumoniae strains isolated in 15 centres of Central (Moscow – 5 centers, Kazan, Nizniy Novgorod, Ryzan), North-Western (Smolensk, Saint-Petersburg), Southern (Krasnodar) regions, Urals (Ekaterinburg) and Siberia (Novosibirsk, Tomsk) were included in this study. Susceptibility to 19 antimicrobials – penicillin G, amoxicillin, amoxicillin/clavulanate, cefotaxime, cefepime, erythromycin, azithromycin, clarithromycin, midecamycin, midecamycin acetate, spiramycin, clindamycin, tetracycline, ciprofloxacin, levolfloxacin, chloramphenicol, co-trimoxazole, rifampicin and vancomycin – was determined by broth microdilution in accordance with NCCLS recommendations.