COVID19 pandemic is a «pandemic» of antimicrobial therapy

The article presents a critical analysis of antibiotic usage tactics in the treatment of patients with COVID-19 existing in Russian and foreign healthcare, and discusses the possible causes of unjustified antibiotic aggression in this category of …

The prevalence of circulating S. pneumoniae serotypes in people older than 18 years: healthy carriers, patients with acute otitis media, community-acquired pneumonia, and invasive pneumococcal infections (epidemiological study «SPECTRUM»)

Objective. To estimate the prevalence of S. pneumoniae serotypes in adults aged of 18 years and older, including healthy carriers and patients with acute otitis media (AOM), community-acquired pneumonia (CAP) and invasive pneumococcal infection (IPI). Materials and Methods. A total of 230 isolates of S. pneumoniae from 10 centers were included in the study from 01.06.2019 to 01.10.2019. Re-identification and typing using real-time PCR with 22 primer pairs were performed in the central laboratory (Institute of Antimicrobial Chemotherapy, Russia).

Bacterial infections in patients with liver cirrhosis

Patients with liver cirrhosis are at substantial risk of bacterial infections. Bacterial complications account for more than 30% of hospitalizations and contribute significantly to mortality among cirrhotic patients. The most common bacterial …

A Clinical Case of Acute Herpesvirus and Pneumocystis Co-infection in a Patient with Progressive Pulmonary Tuberculosis

This article describes a clinical case of fatal polymicrobial pneumonia in a patient with progressive pulmonary tuberculosis. The clinical case represents a co-infection with tuberculosis, viral and pneumocystis infection in a HIV-uninfected patient …

Use of PCR for Diagnosis of Legionella Infection in Hematological Patients

Objective. To assess efficacy of PCR for detection of Legionella in bronchoalveolar lavage (BAL) fluid obtained from hematological patients with pneumonia and acute respiratory failure. Materials and Methods. A total of 79 BAL samples collected from the hospitalized hematological patients with pneumonia and acute respiratory failure (during the 2011–2014) were analyzed using PCR. All BAL samples have been tested for legionellosis by culture immediately after collection, and then stored at –70 °C.

Administration of Antimicrobials into Respiratory Tract: Methods to Improve Efficacy in the Treatment of Hospital-Acquired Pneumonia

Despite the availability of substantial theoretical benefits, the method of antibacterial administration via the respiratory tract to treat acute pneumonia has yet to be widely implemented in clinical practice. The introduction of the method is …

Cefditoren Pivoxil: Clinical, Pharmacological, and Microbiological Aspects

Cefditoren is a 3rd generation, broad-spectrum oral cephalosporin recently approved for the treatment of acute sinusitis, streptococcal pharyngitis/tonsillitis, bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, and …

Ceftaroline: Before Start of Using in Russia

Bacteriological and clinical data on the novel cephalosporin antibiotic ceftarolin fosamil is reviewed. Ceftarolin may be considered as promising drug in Russia due to potent anti-MRSA and antipneumococcal activity, broad spectrum and low toxicity.

Methodology Issues of Legionella Pneumonia Diagnosis in Medical Institutions (Part 2)

Objective. To use algorithm of microbiologic and epidemiologic methods when detecting two or more cases of legionellosis in the medical institution, in accordance with the international guidelines and to assess its efficacy. Materials and Methods. A total of 76 hematological patients with pneumonia and acute respiratory failure were tested for legionellosis using bronchoalveolar lavage (BAL) fluid culture and Legionella urinary antigen test between December 2010 and January 2013. Water samples obtained from the institution’s hot water supply system were tested for Legionella by the standard microbiology method.

Analysis of Antiviral and Antibacterial Therapy in Patients with Influenza A/H1N1 and Pneumonia

Analyzing the cases of treatment of pneumonia with influenza A/H1N1 in the background, it was noted that the outpatient antiviral therapy was provided mainly by «Arbidol». Neuraminidase inhibitors (Oseltamivir and Zanamivir) were used very …