pathogens

Antimicrobial resistance is a global challenge for human society. Scientists around the world are trying not to return to the time when antimicrobials were not yet discovered, and millions of people were dying from infections. This article describes …

Objective. To assess a potential for the use of fosfomycin as a component of polymethyl methacrylate-based bone cement in the topical treatment of periprosthetic infection. Materials and Methods. The most common pathogens of periprosthetic joint infection isolated during the 2013–2014 were studied. Susceptibility of 358 S. aureus and 19 E. coli strains to vancomycin, fosfomycin, and gentamicin was determined. Antimicrobial activity duration for the control samples of the gentamicin-containing bone cement (DEPUY CMW 1 GENTAMICIN) and the experimental samples with addition (per 20 g of cement) of 1 g or 2 g of vancomycin (5% or 10%), 2 g or 4 g of fosfomycin (10% or 20%) was investigated.

This paper provides the results of a study to determine spectrum of pathogens causing bacterial keratitis and their antimicrobial susceptibility. A total of 62 patients with keratitis were examined over the period of 2010–2012. The most common …

This paper presents the results of a study to evaluate pharmacological therapy in inflammatory diseases of maxillofacial area in outpatient and hospital settings. The study included a review of medical records for outpatients (n = 600) and …

This paper presents the results of the study to evaluate knowledge level of ophthalmologists on risk factors, etiology, diagnosis, and treatment of keratitis. A total of 65 ophthalmologists in 3 regions (Smolensk, Kaluga, and Orel) completed …

Objective. To study prospectively clinical course of hospital-acquired pneumonia (HAP), mortality, and risk factors for poor outcome as well as etiology and antibiotic resistance of HAP in trauma patients; to assess antimicrobial therapy in patients with head trauma and orthopedic trauma in Smolensk Clinical Hospital of Emergency Medical Care. Materials and Methods. A prospective observational study in 96 patients with head trauma or orthopedic trauma and concurrent HAP, confirmed by clinical examination, chest X-ray, and Clinical Pulmonary Infection Scale (CPIS) score of ≥5.

To study the microbial and susceptibility patterns in COPD patients with acute respiratory failure (ARF) we performed a prospective cohort study in patients with ARF admitted to our acute care hospital. Quantitative cultures of expectorated sputum or …