mortality | CMAC


COVID-19 risk factors for mortality in hospitalized patients: results of a retrospective study

Objective. To identify risk factors for fatal outcome and COVID-19-associated liver damage in hospitalized adult patients with coronavirus infection. Materials and Methods. In a retrospective cohort study, 389 cases of patients with coronavirus infection complicated by bilateral viral pneumonia were studied. Demographic characteristics, clinical features of the course of the disease, anamnestic data, results of laboratory and instrumental methods of examination were analyzed and correlated with mortality. At the time of admission, the following were taken into account: fever, severity of the patient’s condition according to COVID-19 classification of severity, body mass index (BMI), oxygen saturation (SpO2), percentage of lung tissue damage according to computed tomography (CT).

Antimicrobial therapy of sepsis caused by carbapenem-resistant Klebsiella pneumoniae in patients with hematological malignancies

Objective. To compare the efficacy of ceftazidime-avibactam and aztreonam combination therapy with “standard” therapy in patients with hematological malignancies and sepsis, caused by carbapenemresistant K. pneumoniae. Materials and Methods. In this open, single center prospective-retrospective, cohort study, during 2019–2022, we analyze medical documentation of 81 hospitalized patients with hematologic malignancies and K. pneumoniae sepsis. K. pneumoniae was identified by MALDI-TOF mass-spectrometry; antimicrobial susceptibility testing was performed in accordance with current versions of EUCAST guidelines.

Translocation of gut microbiota in liver cirrhosis: mechanisms, clinical significance, and markers

This article is an overview of the data on bacterial intestinal translocation. The article reviews changes in the intestinal microbiome, the local physiological barrier, as well as the innate and adaptive immunity characteristics contributing to the …

Regional spread of Candida auris

The geographical routes and time schedule of spread of C. auris – the fungus first identified in 2009 are discussed. Data on the increasing frequency of C. auris infections and rapid dissemination of the fungus from the regions of origin – southern …

Etiology of community-acquired pneumonia and prevalence of comorbidities in elderly patient population

Objective. To investigate the mortality rate, comorbidity prevalence, and etiology of community-acquired pneumonia (CAP) in elderly patient population. Materials and Methods. Hospitalized elderly patients with CAP were distributed into the following age groups: 65–74 years (group I), 75–84 years (group II) and 85–94 years (group III). The patients’ medical records were used for determining comorbidities and mortality rate. In order to determine etiology of CAP, sputum or BAL samples were collected.

Questionable Efficacy of Generics in the Treatment of Severe Community-Acquired Pneumonia

The retrospective analysis of treatment of patients with severe community-acquired pneumonia has been performed. It has demonstrated that the results of therapy with generic preparations of ceftriaxone and levofloxacin were inferior to original drug …

The Importance of the Adequate Empiric Antimicrobial Therapy in Nosocomial Infections Caused by Acinetobacter baumannii

Objective. To evaluate the influence of adequate empiric antimicrobial therapy for the outcome and the length of hospitalization in patients with nosocomial infections, caused by Acinetobacter baumannii. Materials and Methods. The subject of the research was 42 patients with nosocomial infections, caused by A. baumannii (middle age 53.3±5 year; 61.9% were males). The evaluation of the interrelation between patient’s outcome and adequacy of the empiric antimicrobial therapy was performed using odds ratio method and χ2-criterion to prove the results.

Assessment of Mortality Rate and Efficacy of Antimicrobial Therapy in Patients with Community-Acquired Pneumonia in Sverdlovsk Region

Efficacy of regional standard of care «CommunityAcquired Pneumonia» and Sverdlovsk regional healthcare program «Intensive Care» were assessed. This paper presents results of retrospective analysis of ICU hospitalizations for severe community-acquired …