hematopoietic stem cell transplantation

Objective. To determine frequency and spectrum of cytomegalovirus (CMV) resistance mutations to antiviral drugs in immunocompromised children. To study clinical course of resistant CMV infection in this patient population. Materials and Methods. This prospective study included 120 patients of the Dmitry Rogachev NMRC PHOI who mainly were recipients of allogeneic hematopoietic stem cell transplantation (HSCT) with confirmed CMV infection (median age – 8.9 years). The study inclusion criterion was the possible development of CMV drug resistance.

Objective. To assess the course and outcomes of COVID-19 in recipients of allogeneic and autologous hematopoietic stem cell transplant (HSCT). Materials and Methods. The retrospective study included 44 adult recipients (allogeneic – 33 [75%] and autologous – 11 [25%] of HSCT who diagnosed with COVID-19 after transplantation. Group mostly represented by acute leukemia – 18 (41%) and lymphoma – 10 (22.7%). The median follow-up time since the development of COVID-19 was 231 days (1–818 days), after HSCT – 507.