generics

Carbapenems in the Multidisciplinary Hospital: Some Clinical and Economic Consequences

The changes in carbapenem consumption during 6 consecutive years have been studied in retrospective trial. 88% of carbapenems have been administered in the ICU’s and hematology department. The 3-fold increase of the total consumption during …

Questionable Efficacy of Generics in the Treatment of Severe Community-Acquired Pneumonia

The retrospective analysis of treatment of patients with severe community-acquired pneumonia has been performed. It has demonstrated that the results of therapy with generic preparations of ceftriaxone and levofloxacin were inferior to original drug …

Levofloxacin Efficacy – the Success Predictors

Objective. Aim. To evaluate the comparable solubility of original levofloxacin (Tavanic, Sanofi–Aventis, France) and its generics. Materials and Methods. The resolution kinetics of the original drug and two generics was studied in different рН levels. The choice of рН levels was done according to the US pharmacopeia. Results. The original levofloxacin has shown the stable parameters important for bioavailability independently from рН level. At the same time resolution kinetics of two generic products significantly varied depending on рН.

Specifics of Russian Pharmaceutical Market in the XXI Century: Original Drugs or Generics?

This paper reviews some issues concerning comparison of pharmaceutical quality and bioequivalence between original drug products and their generics. A need for periodic routine monitoring of the currently marketed drug products and more stringent …

Pharmaceutical Quality of Ceftriaxone Generic Drug Products Compared with Rocephin®

Translated and reprinted with permission from “Journal of Chemotherapy” 2003; 15:357-68

The pharmaceutical qualities of 34 ceftriaxone generic products were compared with Rocephin as the reference standard.Quality standards specified in the European …