cephalosporins

Oral third-generation cephalosporins in the treatment of community-acquired urinary tract infections

Cephalosporins are one of the most commonly used antimicrobials for the treatment of variety of bacterial infections. Prudent use of the third-generation cephalosporins is important for the control of spread of cephalosporin-resistant Gram-negative …

Medication errors associated with the use of cephalosporins

Objective. To discover the prevalence and types of medication errors associated with the use of cephalosporins through analysis of national spontaneous reporting database. Materials and Methods. We conducted a retrospective analysis of 2324 spontaneous reports concerning adverse drug reactions associated with the cephalosporins. All the reports were submitted to the Russian pharmacovigilance database between 01.01.2012 and 01.08.2014. Approved prescribing drug information, standards of medical care and practical guidelines for certain conditions were used to identify medication errors associated with specific products.

In vitro Ceftaroline Activity against Major Bacterial Pathogens n Russia: Results of Multicenter Study

Background. Ceftaroline is a new broad-spectrum cephalosporin with in vitro activity against Gram-positive pathogens, including MRSA, and common Gram-negative pathogens. It is approved for the treatment of acute complicated bacterial skin and skin-structure infections (SSSIs) and community-acquired bacterial pneumonia. Objective. To determine in vitro activity of ceftaroline and other clinically available antimicrobials against major bacterial pathogens from different regions of Russian Federation. Materials and Methods. A total of 2778 consecutive, non-duplicate isolates were collected during multicentre microbiological in vitro study from 36 geographically distinct cities of Russia during 2008–2012.

Ceftaroline: Before Start of Using in Russia

Bacteriological and clinical data on the novel cephalosporin antibiotic ceftarolin fosamil is reviewed. Ceftarolin may be considered as promising drug in Russia due to potent anti-MRSA and antipneumococcal activity, broad spectrum and low toxicity.

Ceftaroline – «Sui Generis»

Ceftaroline fosamil is a novel cephalosporin antibiotic that has a high activity against multiple bacterial pathogens, including important drug-resistant microorganisms. The main benefit of the ceftaroline fosamil compared to other beta-lactams is an …

Cephalosporins in the Treatment of Community-Acquired Upper and Lower Respiratory Tract Infections Based on Antimicrobial Resistance Data from Russia

Beta-lactams remain one of the most commonly used antimicrobial classes in the treatment of community-acquired respiratory tract infections worldwide. Among them, cephalosporins take one of the main places because of their broad spectrum of activity …

The Use of Cefixime in the Treatment of Chronic Obstructive Pulmonary Diseases

Cefixime is the first oral 3-rd generation cephalosporin. This antimicrobial agent has good oral bioavailability (40-50%); Cmax in blood (2.6-4.8 mg/I)is achieved in 4 hours after single oral dose, maximal tissue concentration - in 6.7 hours. …

Ceftibuten: Current Role in the Therapy of Infections

Beta-lactams remain the most used class of antibiotics all over the world. Among them, cephalosporins occupy the leading place. This is due to not only wide spectrum of activity, but also a good tolerability of this antibiotic class. Оral therapy …