carbapenemases

Antimicrobial resistance, carbapenemase production, and genotypes of nosocomial Acinetobacter spp. isolates in Russia: results of multicenter epidemiological study ”MARATHON 2015–2016”

Objective. Objectives. To assess the rates of antibiotic resistance and production of acquired carbapenemases in nosocomial strains of Acinetobacter spp., and to determine the genotypes and prevalence of “international high-risk clones” among nosocomial strains of Acinetobacter baumannii isolated in various regions of Russia within the “MARATHON 2015–2016” study. Materials and Methods. A total of 1005 non-duplicate nosocomial isolates of Acinetobacter spp., including 975 isolates of A. baumannii, collected in 44 hospitals from 25 cities in Russia in 2015– 2016 were studied.

Antimicrobial resistance, carbapenemase production, and genotypes of nosocomial Pseudomonas aeruginosa isolates in Russia: results of multicenter epidemiological study “MARATHON 2015–2016”

Objective. Objectives. To assess the rates of antibiotic resistance, production of acquired carbapenemases, genotypes and prevalence of «international high-risk clones» among nosocomial strains of Pseudomonas aeruginosa isolated in various regions of Russia within the «MARATHON 2015–2016» study. Materials and Methods. A total of 1006 non-duplicate nosocomial isolates of P. aeruginosa collected in 44 hospitals from 25 cities in Russia in 2015–2016 were studied. Species identification of isolates was performed by means of MALDI-TOF mass-spectrometry.

Comparative review of the modern methods for carbapenemases detection

Recent emergence and spread of carbapenemase-producing Gram-negative bacteria that hydrolyze most β-lactams, including carbapenems, are a major concern for antimicrobial therapy worldwide, including Russia. This paper presents a comparative review of …

Antimicrobial resistance of Gram-negative pathogens of nosocomial pneumonia in intensive care unit patients

In order to study etiology and antimicrobial resistance rates in Gram-negative pathogens of nosocomial pneumonia, a total of 1410 isolates obtained from sputum in 75 ICU patients with nosocomial pneumonia in 2012 and 2017 was tested. The most common …

Antimicrobal resistance of nosocomial carbapenemase-producing Enterobacterales in Russia: results of surveillance, 2014-2016

Objective. To assess the prevalence and antimicrobial susceptibility of carbapenemase-producing Enterobacterales (CPE). Materials and Methods. A total of 5539 Enterobacterales isolates recovered from hospitalized patients in 52 medical institutions in 27 cities in Russia in 2014-2016 were tested. Antibiotic susceptibility testing (AST) was performed using broth microdilution method according to ISO 20776-1:2006. Avibactam was tested in combinations with beta-lactams at fixed concentration of 4 mg/l. AST results were interpreted according to EUCAST v8.

Pseudomonas aeruginosa: the history of one of the most successful nosocomial pathogens in Russian hospitals

Pseudomonas aeruginosa is recognized as one of the six most important pathogens in terms of antimicrobial resistance («ESKAPE» pathogens), and included by WHO in the group of microorganisms for which the need for development of new antimicrobial …

The molecular characteristics of antibiotic-resistant strains of Klebsiella pneumoniae isolated in traumatology hospitals

This study analyzed a prevalence of carbapenem-resistant Klebsiella pneumoniae strains obtained in the Privolzhsky Federal Medical Research Center units and their antibiotic resistance mechanisms. During the study year, the incidence of K. pneumoniae …

Carbapenemase-producing Gram-negative bacteria in the Russian research center of radiology and surgical technologies

Objective. To assess an incidence rate of carbapenemase-producing Gram-negative bacteria isolated from patients in the RRCRST. Materials and Methods. The clinical Gram-negative isolates obtained from patients hospitalized to the RRCRST over the period of February 2014 to April 2016 were tested. A screening for carbapenem resistance was performed by culture on chromogenic media, and species identification was made using MALDI-TOF massspectrometry. Susceptibility of Gram-negative bacteria to antimicrobial agents was determined using VITEK-2.

Prevalence of carbapenemase-producing Klebsiella pneumoniae isolates in Belarus and their competitive ability

Susceptibility to antibiotics was determined for 208 hospital isolates from 4 regions of Belarus. The broad abundance of resistance to carbapenems was shown. The genes of carbapenemases blaNDM, blaOXA-48 and blaKPC were detected in 55 strains from 12 …

Antimicrobial resistance of nosocomial Pseudomonas aeruginosa isolates in Russia: results of multicenter epidemiological study «MARATHON» 2013-2014

Pseudomonas aeruginosa is the most abundant bacterial species causing nosocomial infections in Russia. In this paper, we report the data on antimicrobial susceptibility of 743 isolates of P. aeruginosa collected in 63 hospitals of 22 cities of Russia …