beta-lactamases

Cefazolin inoculum effect among methicillinsusceptible Staphylococcus aureus isolated from patients with skin infections

Objective. To evaluate frequency and intensity of cefazolin inoculum effect among methicillin-susceptible staphylococci isolated from patients with skin infections. Materials and Methods. A total of 80 methicillin susceptible isolates of Staphylococcus aureus were identified by cefoxitin disk-diffusion test and negative results of real-time PCR for mecA gene. Inoculum effect was measured by broth microdilution test with two inocula with concentrations of 5 × 105 CFU/mL and 5 × 107 CFU/mL.

Mechanisms and regulation of antimicrobial resistance in Pseudomonas aeruginosa

Pseudomonas aeruginosa is a dangerous opportunistic pathogen. One of the most negative clinically significant features of P. aeruginosa is associated with the rapid acquisition of antimicrobial resistance. This review provides an analysis of current …

«Checkerboard Array» as a Test for Evaluation of Decrease in Gram-Negative Bacteria Resistance to Carbapenems in the Presence of Bisphosphonate

One of the main mechanisms of resistance of Gramnegative microorganisms to antibiotics is enzymatic hydrolysis by beta-lactamases (for example, metallobeta-lactamases). Searching of paths of strengthening of carbapenems action is possible due to …

Amoxicillin/Sulbactam – a New Beta-Lactam/Beta-Lactamase Inhibitor Combination

Beta-lactams are the most commonly used class of antimicrobial agents for the treatment of community-acquired and nosocomial infections. One of the resistance mechanisms for this class is a production of beta-lactamases. To overcome this problem, the …