Acinetobacter baumannii

Potentiation of antimicrobial activity of colistin with antibiotics of different groups against multidrug- and extensively drug-resistant strains of Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa

Objective. To reveal antibiotics being capable of potentiating the antimicrobial activity of colistin against multidrug- and extensively drug-resistant strains of Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. Materials and Methods. The minimum inhibitory concentrations (MIC) of colistin alone and in combination with fixed concentrations of antibiotics of different groups were determined for 272 multidrug- and extensively drug-resistant strains of K. pneumoniae, A. baumannii and P. aeruginosa. Bactericidal activity of colistin, carbapenems, clarithromycin and their combinations were also determined at fixed PK/PD breakpoint concentrations of antibiotics.

Detection of acquired carbapenemase genes among Acinetobacter baumannii isolated from blood culture in patients with hematological malignancies

Objective. To evaluate the prevalence of acquired carbapenemase genes among A. baumannii isolates collected from blood culture in patients with hematological malignancies. Materials and Methods. This prospective multicenter study included A. baumannii isolated from blood culture in hematological patients in 7 Russian hospitals (2003–2015). Minimum inhibitory concentrations (MICs) of meropenem and imipenem were determined by broth microdilution method (CLSI, 2017). All A. baumannii isolates were tested by multiplex real-time PCR for presence of acquired carbapenemase genes (blaOXA-23-like, blaOXA-24⁄40-like, blaOXA-58-like, blaNDM-like, blaVIM-like and blaIMP-like).

Susceptibility to antibiotic combinations among nosocomial carbapenemase-producing Gram-negative bacteria isolated in Belarus

Objective. To assess a susceptibility to antibiotic combinations in nosocomial carbapenemase-producing Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii isolates using a modified method of multiple combination bactericidal testing (MCBT). Materials and Methods. A total of 178 isolates (63 K. pneumoniae isolates, 31 P. aeruginosa isolates, 84 A. baumannii isolates) obtained in the 2013-2017 from hospitalized patients in 28 public health organizations in 4 Belarus regions were included in the study.

Genotyping Analysis of Nosocomial Acinetobacter baumannii Strains

The problem of genotypic variety of Acinetobacter baumannii isolated from patients with healthcare associated infections (HCAIs) are discussed. Carbapenemresistant strains, which are predominant in the study region, were shown to belong to the …

Characteristics of Nosocomial Strains of Acinetobacter spp. in a Trauma Center

Incidence rates of Acinetobacter spp. isolated from tissue specimens and wound samples in patients with severe burns, chronic osteomyelitis, and diabetic foot infections were determined during the 5 years (2008– 2012). Antimicrobial resistance of …

The Importance of the Adequate Empiric Antimicrobial Therapy in Nosocomial Infections Caused by Acinetobacter baumannii

Objective. To evaluate the influence of adequate empiric antimicrobial therapy for the outcome and the length of hospitalization in patients with nosocomial infections, caused by Acinetobacter baumannii. Materials and Methods. The subject of the research was 42 patients with nosocomial infections, caused by A. baumannii (middle age 53.3±5 year; 61.9% were males). The evaluation of the interrelation between patient’s outcome and adequacy of the empiric antimicrobial therapy was performed using odds ratio method and χ2-criterion to prove the results.

Non-Fermenting GramNegative Nosocomial Pathogens in Russian ICUs: Antimicrobial Resistance Problems

In vitro susceptibility study strains of Acinetobacter baumannii and Pseudomonas aeruginosa isolated from patients with nosocomial infections in 31 Russian ICUs was performed (in the framework of «RESORT» survey). The following antibiotics were …