Aetiology of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation

Clinical Microbiology and Antimicrobial Chemotherapy. 2018; 20(3):232-238

​ Vasilieva V.A., Parovichnikova E.N., Drokov M.Yu., Kuzmina L.A., Klyasova G.A., Tikhomirov D.S., Tupoleva T.A., Koroleva O.M., Dubnyak D.S., Mikhaltsova E.D., Popova N.N., Konova Z.V., Savchenko V.G.
10.36488/cmac.2018.3.232-238
hemorrhagic cystitis allogeneic hematopoietic stem cell transplantation polyomavirus herpesvirus
Section
Personal Experience
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2018; 20(3):232-238

Abstract

Incidence, severity, and risk factors for hemorrhagic cystitis (HC) were assessed in 267 patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). HC was diagnosed in 14.6% (39 patients) within 1-139 days after allo-HSCT (median duration – 39 days). Chemotherapy-related HC was diagnosed in 4 patients only. The majority (19⁄35) of patients developed late HC of viral aetiology. Median time from a day of HC diagnosis to clinical symptoms resolution was 25 days (range: 6 to 133 days). Using a multivariate analysis, allo-HSCT from mismatched unrelated/haploidentical donor was found to be a risk factor of HC (р=0.01). The analysis also showed that 82.1% of patients with HC received cyclophosphamide as a part of conditioning regimen or +3/+4 days after allo-HSCT.

Vera A. Vasilieva

National Medical Research Center of Hematology, Moscow, Russia

Parovichnikova E.N.

National Medical Research Center of Hematology, Moscow, Russia

Drokov M.Yu.

National Medical Research Center of Hematology, Moscow, Russia

Kuzmina L.A.

National Medical Research Center of Hematology, Moscow, Russia

Galina A. Klyasova

National Medical Research Center of Hematology, Moscow, Russia

Tikhomirov D.S.

National Medical Research Center of Hematology, Moscow, Russia

Tupoleva T.A.

National Medical Research Center of Hematology, Moscow, Russia

Koroleva O.M.

National Medical Research Center of Hematology, Moscow, Russia

Dubnyak D.S.

National Medical Research Center of Hematology, Moscow, Russia

Mikhaltsova E.D.

National Medical Research Center of Hematology, Moscow, Russia

Popova N.N.

National Medical Research Center of Hematology, Moscow, Russia

Konova Z.V.

National Medical Research Center of Hematology, Moscow, Russia

Savchenko V.G.

National Medical Research Center of Hematology, Moscow, Russia

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