Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19(2):161-167
The results of hepatitis markers prevalence estimation and the immune response intensity and duration in hospital staff (Buryatiya, Ulan-Ude, n=611 and Moscow, n=653) after vaccination against hepatitis B are presented. HBV serological markers were revealed in 259 (42.5%) and 70 (11.7%) persons: HBsAg (2.6% versus 0.2%; p<0.05), anti-HBs in a combination with anti-HBc (35.0% versus 10.7%; p<0.05), only anti-HBc (4.9% versus 0.8%; p<0.05) among Ulan-Ude and Moscow medical personnel, respectively. HBV DNA positive in PCR isolates had genotype D (90.9%), subtypes ayw3 and ayw2. HBV genotype D has been established in 90.9% of isolates and genotype A in 9.1% (Ulan-Ude). Prevalence of subtypes HBsAg in our research was 9.1% (ad) and (90.9% (ay). Anti-HCV were revealed in 3.3% and 2.9%, HCV RNA – in 41.2% and 36.8%, genotype 1 HCV – in 57.1% and 85.7%, genotype 3 HCV in 28.6% and 14.3% of cases in Ulan-Ude and Moscow, respectively. The question of the selection of vaccines with dominant among the population of Russia HBsAg subtype ay for the improvement of immunization programs is discussed.