Clinical Microbiology and Antimicrobial Chemotherapy. 2016; 18(2):113-124
Bifidobacterium lactis BB-12 and Lactobacillus acidophilus LA-5 are the well-known probiotic strains. This review presents data on efficacy of the administration of BB-12 and LA-5 strains in several GI tract disorders: treatment of diarrhea, prevention of antibiotic-associated diarrhea, adjuvant therapy of Helicobacter pylori-associated diseases, treatment of functional constipation, and normalization of bowel function. The data on multiple effects of BB-12 and LA-5 strains on immune system function (decrease in rate of respiratory tract infections in children, prevention and treatment of atopic diseases) are also described. A focus on safety of probiotic administration, including the use in vulnerable patient populations, is made.