Efficacy and Safety of Lactobacillus acidophilus LA-5 and Bifidobacterium lactis BB-12 Combination in Gastroenterology, Pediatrics and Allergology

Clinical Microbiology and Antimicrobial Chemotherapy. 2016; 18(2):113-124

Journal article


Bifidobacterium lactis BB-12 and Lactobacillus acidophilus LA-5 are the well-known probiotic strains. This review presents data on efficacy of the administration of BB-12 and LA-5 strains in several GI tract disorders: treatment of diarrhea, prevention of antibiotic-associated diarrhea, adjuvant therapy of Helicobacter pylori-associated diseases, treatment of functional constipation, and normalization of bowel function. The data on multiple effects of BB-12 and LA-5 strains on immune system function (decrease in rate of respiratory tract infections in children, prevention and treatment of atopic diseases) are also described. A focus on safety of probiotic administration, including the use in vulnerable patient populations, is made.

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