oney in the Treatment of Infected Wounds | CMAC

oney in the Treatment of Infected Wounds

Clinical Microbiology and Antimicrobial Chemotherapy. 2014; 16(3):219-228

​ Privolnev V.V., Danilenkov N.V.
honey antimicrobial activity wound infection
Section
Antimicrobials
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2014; 16(3):219-228

Abstract

Honey is a traditional topical treatment for infected wounds was rediscovered in recent years. There are now many published reports describing the effectiveness of honey in rapidly clearing infection from wounds, with no adverse effects. In laboratory studies, it has been shown to have an antimicrobial action against a broad spectrum of bacteria and fungi. It can be effective on antibioticresistant strains of bacteria.

  • 1. Gunther R.T. The Greek Herbal of Dioscorides. New York: Hafner; 1934 (reprinted 1959).
  • 2. Molan P.C. The antibacterial activity of honey. The nature of the antibacterial activity. Bee World 1992; 73(1):5-28.
  • 3. Molan P.C. The evidence and the rationale for the use of honey as a wound dressing. Wound Practice and Research 2011; 19(4):204–20.
  • 4. Molan P.C. The role of honey in the management of wounds. J Wound Care 1999; 8:415–8.
  • 5. Dustmann J.H. Antibacterial effect of honey. Apiacta 1979; 14:7-11.
  • 6. Bose B. Honey or sugar in treatment of infected wounds? Lancet 1982; 1:963.
  • 7. Condon R.E. Curious interaction of bugs and bees. Surgery 1993; 113(2):234-5.
  • 8. Green A.E. Wound healing properties of honey. Br J Surg 1988; 75(12):1278.
  • 9. Keast-Butler J. Honey for necrotic malignant breast ulcers. Lancet 1980; 2(8198):809.
  • 10. Mossel D.A. Honey for necrotic breast ulcers. Lancet 1980; 2(8203):1091.
  • 11. Seymour F.I, West K.S. Honey – its role in medicine. Med Times 1951; 79:104-7.
  • 12. Somerfield S.D. Honey and healing. J R Soc Med 1991; 84(3):179.
  • 13. Tovey F.I. Honey and healing. J R Soc Med 1991; 84(7):447.
  • 14. Chirife J., Herszage L., Joseph A., Kohn E.S. In vitro study of bacterial growth inhibition in concentrated sugar solutions: microbiological basis for the use of sugar in treating infected wounds. Antimicrob Agents Chemother 1983; 23(5):766-73.
  • 15. Efem S.E. Clinical observations on the wound healing properties of honey. Br J Surg 1988; 75(7):679-81.
  • 16. Cavanagh D., Beazley J., Ostapowicz F. Radical operation for carcinoma of the vulva. A new approach to wound healing. J Obstet Gynaecol Br Commonw 1970; 77(11):1037-40.
  • 17. Armon P.J. The use of honey in the treatment of infected wounds. Trop Doct 1980; 10(2):91.
  • 18. Braniki F.J. Surgery in Western Kenya. Ann R Coll Surg Engl 1981; 63:348-52.
  • 19. Cooper R.A., Molan P.C., Harding K.G. Antibacterial activity of honey against strains of Staphylococcus aureus from infected wounds. J R Soc Med 1999; 92(6):283-5.
  • 20. Привольнев В.В., Каракулина Е.В. Основные принципы местного лечения ран и раневой инфекции. Клин микробиол антимикроб химиотер 2011; 13(3):214-22.
  • 21. Sackett W.G. Honey as a carrier of intestinal diseases. Bull Colorado State Univ Agric Exp Stn 1919; 252:1-18.
  • 22. White J.W, Subers M.H, Schepartz A.I. The identification of inhibine, the antibacterial factor in honey, as hydrogen peroxide and its origin in a honey glucoseoxidase system. Biochim Biophys Acta 1963; 73:57-70.
  • 23. Dold H., Witzenhausen R. Ein Verfahren zur Beurteilung der еrtlichen inhibitorischen (keimvermehrungshemmenden) Wirkung von Honigsorten verschiedener Herkunft [Method of evaluation of the local inhibitory (antibacterial) substances of honeys from various origins]. Z Hyg Infektionskr 1955; 141:333-7.
  • 24. Postmes T.J, Bosch M.M.C, Dutrieux R., van Baare J., Hoekstra M.J. Speeding up the healing of burns with honey. An experimental study with histological assessment of wound biopsies. In: Mizrahi A., Lensky Y., editors. Bee Products: Properties, Applications and Apitherapy. New York: Plenum Press, 1997; 27-37.
  • 25. Turner F.J. Hydrogen Peroxide and Other Oxidant Disinfectants (3rd ed). Philadelphia: Lea and Febiger, 1983.
  • 26. Salahudeen A.K., Clark E.C., Nath K.A. Hydrogen peroxide-induced renal injury. A protective role for pyruvate in vitro and in vivo. J Clin Invest 1991; 88(6):1886-93.
  • 27. Блатун Л.А. Местное медикаментозное лечение ран. Хирургия. Журнал им. Н.И. Пирогова 2011; 4:51-59
  • 28. Светухин А.М., Блатун Л.А., Адамян А.А. Раны, инфекции, лечебные повязки. Аптечное дело 2002; 10:16
  • 29. Bunting C.M. The production of hydrogen peroxide by honey and its relevance to wound healing. MSc thesis. University of Waikato. 2001.
  • 30. Frankel S., Robinson G.E, Berenbaum M.R. Antioxidant capacity and correlated characteristics of 14 unifloral honeys. J Apic Res 1998; 37(1):27-31.
  • 31. Henriques A. Free radical production and quenching in honeys with wound healing potential. J Antimicrob Chemother 2006; 58(4):773–7
  • 32. van den Berg A.J. An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey. J Wound Care 2008; 17(4):172–8
  • 33. Hyslop P.A., Hinshaw D.B., Scraufstatter I.U., Cochrane C.G., Kunz S., Vosbeck K. Hydrogen peroxide as a potent bacteriostatic antibiotic: implications for host defense. Free Radic Biol Med 1995; 19(1):31-7.
  • 34. Kumar A., Sharma V.K., Singh H.P., Prakash P., Singh S.P. Efficacy of some indigenous drugs in tissue repair in buffaloes. Indian Vet J 1993; 70(1):42-4.
  • 35. Kandil A., El-Banby M., Abdel-Wahed K., AbouSehly G., Ezzat N. Healing effect of true floral and false non-floral honey on medical wounds. J Drug Res (Cairo) 1987; 17(1-2):71-5.
  • 36. Abuharfeil N., Al-Oran R., Abo-Shehada M. The effect of bee honey on the proliferative activity of human B- and T-lymphocytes and the activity of phagocytes. Food Agric Immunol 1999; 11:169-77.
  • 37. Tonks A., Cooper R.A., Price A.J., Molan P.C., Jones K.P. Stimulation of tnf-alpha release in monocytes by honey. Cytokine 2001; 14(4):240-2.
  • 38. Ryan G.B., Majno G. Inflammation. Michigan: Upjohn, 1977.
  • 39. Gethin G.T., Cowman S. Manuka honey vs. hydrogel – a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. J Clin Nurs 2009; 18(3):466-74.
  • 40. Tarnuzzer R.W., Schultz G.S. Biochemical analysis of acute and chronic wound environments. Wound Repair Regen 1996; 4(3):321-5.
  • 41. Floris I., Prota R. Sul miele amaro di Sardegna [Bitter honey from Sardegna]. Apic Mod 1989; 80(2):55-67.
  • 42. Fotidar M.R., Fotidar S.N. ‘Lotus’ honey. Indian Bee J 1945; 7:102.
  • 43. Abbas T. Royal treat. Living in the Gulf 1997; 50-1.
  • 44. Mavric E., Wittmann S., Barth G. Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand Molecular Nutrition & Food Research 2008; 52:483-89.
  • 45. Willix D.J., Molan P.C., Harfoot C.G. A comparison of the sensitivity of wound-infecting species of bacteria to the antibacterial activity of manuka honey and other honey. J Appl Bacteriol 1992; 73(5):388-94.
  • 46. Cooper R.A., Molan P.C. The use of honey as an antiseptic in managing Pseudomonas infection. J Wound Care 1999; 8(4):161-4.
  • 47. Allen K.L., Hutchinson G., Molan P.C. The potential for using honey to treat wounds infected with MRSA and VRE. First World Wound Healing Congress, 2000; Melbourne, Australia.
  • 48. Cooper R.A., Halas E., Davies R., Molan P.C., Harding K.G. The inhibition of Gram-positive cocci of clinical importance by honey. First World Wound Healing Congress, 2000; Melbourne, Australia.
  • 49. Cooper R.A. The efficacy of honey in inhibiting strains of Pseudomonas aeruginosa from infected burns. J Burns Care Rehabil 2002; 23:366-70.
  • 50. Blair S.E. The unusual antibacterial activity of medicalgrade Leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis. Eur J Clin Microbiol Infect Dis 2009; 28(10):1199-208.
  • 51. Henriques A.F. The intracellular effects of manuka honey on Staphylococcus aureus. Eur J Clin Microbiol Infect Dis 2010; 29(1):45-50.
  • 52. George N.M., Cutting K.F. Antibacterial honey (MedihoneyTM): in vitro activity against clinical isolates of MRSA, VRE, and other multiresistant gram-negative organisms including Pseudomonas aeruginosa. Wounds 2007; 19(9): 231-6
  • 53. Sherlock O. Comparison of the antibacterial activity of Ulmo honery from Chile and manuka honey against methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. BMC Complement Altern Med 2010; 2(10):47.
  • 54. Jenkins R. Manuka honey inhibits cell division in methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 2011; 66(11):2536-4.
  • 55. French V.M. The antibacterial activity of honey against coagulase-negative staphylococci. J Antimicrob Chemother 2005; 56:228-31.
  • 56. Cooper R.A. Testing the susceptibility to manuka honey of streptococci isolated from wound swab. J ApiProduct & ApiMedical Science 2011; 3(3):117–22.
  • 57. Привольнев В.В., Родин А.В., Каракулина Е.В. Местное применение антибиотиков в лечении инфекций костной ткани. Клин микробиол и антимикроб химиотер 2012; 14(2):118-32.
  • 58. Merckoll P. Bacteria, biofilm and honey: a study of the effects of honey on ‘planktonic’ and biofilm-embedded chronic wound bacteria. Scand J Infect Dis 2009; 41(5):341-7.
  • 59. Alandejani T. Effectiveness of honey on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Otolaryngol Head Neck Surg 2009; 141(1):114-8.
  • 60. Okhiria O.A. Honey modulates biofilms of Pseudomonas aeruginosa in a time and dose dependent manner. J ApiProduct & ApiMedical Science 2009; 1(1):6-10.
  • 61. Cooper R. Inhibition of biofilms through the use of manuka honey. Wounds UK 2011; 7(1):24-32.
  • 62. Maddocks S.E. Manuka honey inhibits the development of Streptococcus pyogenes biofilms and causes reduced expression of two fibronectin binding proteins. Microbiology 2012; 158:781-90.
  • 63. Jervis-Bardy J. Methylglyoxal-infused honey mimics the anti-Staphylococcus aureus biofilm activity of manuka honey: potential implication in chronic rhinosinusitis. Laryngoscope 2011; 121(5):1104-7.
  • 64. Hutton D.J. Treatment of pressure sores. Nurs Times 1966; 62(46):1533-4.
  • 65. Efem S.E. Recent advances in the management of Fournier’s gangrene: preliminary observations. Surgery 1993; 113(2):200-4.
  • 66. Harris S. Honey for the treatment of superficial wounds: a case report and review. Primary Intention 1994; 2(4):18- 23.
  • 67. Dunford C., Cooper R., Molan P. Using honey as a dressing for infected skin lesions. Nurs Times 2000; 96(14 Suppl):7-9.
  • 68. Dunford C., Cooper R., White R.J., Molan P. The use of honey in wound management. Nurs Standard 2000; 15(11):63-8.
  • 69. Natarajan S., Williamson D., Grey J.A., Harding K.G., Cooper R.A. Healing of an MRAS-colonised, hydroxyurea-induced leg ulcer with honey. J Dermat Treat 2001; 12:33-6.
  • 70. Al-Waili N.S., Saloom K.Y. Effects of topical honey on post-operative wound infections due to gram positive and gram negative bacteria following caesarean sections and hysterectomies. Eur J Med Res 1999; 4(3):126-30.
  • 71. Subrahmanyam M. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns 1998; 24(2):157-61.
  • 72. Ефименко Н.А., Привольнев В.В. Гангрена Фурнье. Клин микробиол антимикроб химиотер 2008; 10(1):25-34.
  • 73. Привольнев В.В., Савкин В.А.. Клиническая значимость и опыт лечения больных с гангреной Фурнье. Клиническая медицина 2008; 3(15):120-5.
  • 74. Oryan A., Zaker S.R. Effects of topical application of honey on cutaneous wound healing in rabbits. Zentralbl Veterinarmed A 1998; 45:181-8.
  • 75. Rashad U.M., Al-Gezawy S.M., El-Gezawy E., Azzaz A.N. Honey as topical prophylaxis against radiochemotherapyinduced mucositis in head and neck cancer. J Laryngol Otol 2009; 123:223-8.
  • 76. Ingle R., Levin J., Polinder K. Wound healing with honey-a randomised controlled trial. S Afr Med J 2006; 96:831-5.
  • 77. Marshall C., Queen J., Manjooran J. Honey vs povidine iodine following toenail surgery. Wounds 2005; 1(1):10-8.
  • 78. Jull A.B., Rodgers A., Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev 2008(4): CD005083.
  • 79. Mashhood A.A., Khan T.A., Sami A.N. Honey compared with 1% silver sulfadiazine cream in the treatment of superficial and partial thickness burns. J Pak Assoc Dermatol 2006; 16:14-9.
  • 80. Subrahmanyam M. Honey impregnated gauze versus polyurethane film (OpSite) in the treatment of burns-a prospective randomised study. Br J Plast Surg 1993; 46:322-3.
  • 81. Bangroo A.K., Katri R., Chauhan S. Honey dressing in pediatric burns. J Indian Assoc Pediatr Surg 2005; 10:172-5.
  • 82. Subrahmanyam M., Sahapure A.G., Nagane N.S., Bhagwat V.R., Ganu J.V. Effects of topical application of honey on burn wound healing. Ann Burns Fire Disasters 2001; 14(3):22-4.
  • 83. Привольнев В.В., Решедько Г.К., Земляной А.Б., Бублик Е.В. Лечение пациентов с синдромом диабетической стопы в г. Смоленске по результатам анкетирования. Доктор.Ру 2012; 1(69):65-70.
  • 84. Shukrimi A., Sulaiman A.R., Halim A.Y., Azril A. A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers. Med J Malaysia 2008; 63(1):44-6.
  • 85. Bauer L., Kohlich A., Hirschwehr R., et al. Food allergy to honey: pollen or bee products? Characterization of allergenic proteins in honey by means of immunoblotting. J Allergy Clin Immunol 1996; 97(1 Pt 1):65-73.
  • 86. Betts J.A., Molan P.C. A pilot trial of honey as a wound dressing has shown the importance of the way honey is applied to wounds. 11th Conference of the European Wound Management Association, 2001; Dublin, Ireland.
  • 87. Molan P.C., Allen K.L. The effect of gamma-irradiation on the antibacterial activity of honey. J Pharm Pharmacol 1996; 48(11):1206-9.
Views
0 Abstract
0 PDF
0 Crossref citations
Shared