Properties of Pseudomonas aeruginosa Strains Causing Nosocomial Infections in Surgical Wards in Federal Scientific Center of Transplantology and Bioartificial Organs | CMAC

Properties of Pseudomonas aeruginosa Strains Causing Nosocomial Infections in Surgical Wards in Federal Scientific Center of Transplantology and Bioartificial Organs

Clinical Microbiology and Antimicrobial Chemotherapy. 2012; 14(2):88-99

Type
Journal article

Abstract

Pseudomonas aeruginosa is the opportunistic microorganism dominating in intensive care units. The present research has been devoted to studying of the causes of long-lasting circulation of certain genotype of P. aeruginosa strains in Federal Scientific Center of Transplantology and Bioartificial Organs. MLST has shown that a leading genotype is ST 235. The strains of this genotype are characterized by the presence of chromosomal mobile integrons class I with gene cassette blaGES5 and aadA6 determining multidrug resistance. These integrons differ from the integrons previously detected in strains of ST 235 in other medical institutions. P. aeruginosa strains of genotype 446 are closely related to the toxigenic strain PA-103. Strains of ST 446, 598 and 966, and the majority of the strains of the nonfermentative bacilli, identified by pheno- and genotyping as Acinetobacter baumannii, Stenotrophomonas maltophilia and Oceanobacillus spp., contain a functional integron platform and can be potential acceptors of the genes providing adaptation in a hospital. It is shown that the P. aeruginosa strain, allocated from water supply system, is not the agent of hospital infections at patients.

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