Clinical Microbiology and Antimicrobial Chemotherapy. 2011; 13(2):149-157
Nosocomial meningitis is one of the life-threatening complications following head injury and neurosurgery interventions. The prevalence of nosocomial meningitis varies widely (0.8% to 17% of the patients undergoing neurosurgery). Nosocomial meningitis poses an increased risk of poor (fatal) outcome. The mortality in neurosurgery patients with nosocomial meningitis is as high as 20% to 50%. Diagnosis of nosocomial meningitis is based on clinical data and results of cerebrospinal fluid analysis, serum chemistry, and microbiological tests. This paper reviews the most recent data on etiology, pathogenesis, diagnosis and treatment of patients with nosocomial meningitis.