Clinical Microbiology and Antimicrobial Chemotherapy. 2010; 12(3):246-252
Analysis of susceptibility to carbapenems of P. aeruginosa (n=178) isolated in different Perm city hospitals showed that the majority of carbapenem-resistant strains were obtained from intensive care units (ICU) patients in surgical hospitals. The maternity hospital and the child hospital were dominated by isolates susceptible to this antimicrobial class. Overall proportion of meropenemresistant P. aeruginosa isolates was 42.5%; imipenemresistant isolates accounted for more than 50%. A total of 32.4% of strains were resistant to both meropenem and imipenem concomitantly. Production of metallo-betalactamases was observed in 19.1% isolates (among all strains tested) or 30.3% isolates (among carbapenemresistant strains). These strains were found to carry blaVIM-2 genes. Comparative analysis of several amino acid sequences of beta-lactamases showed that the enzymes belong to VIM-2-like group.