Abstract
Bacterial vaginosis is a common disease of female genital tract. It is characterised by substitution of lactobacteriae, which are predominant part of normal vaginal flora, with Gardnerella vaginalis and anaerobes, and has serious social and medical consequences. Tinidazole (second generation 5-nitro-imidazole) is at least as effectve as standard treatments of bacterial vaginosis, such as metronidazole and clindamycin, and demonstrates better tolerability compared to metronidazole. Therefore, tinidazole may be an option in the treatment of this disease.
-
1.
Кудрявцева Л.В., Ильина Е.Н., Говорун В.М., Минаев В.И., Зайцева С.В., Липова Е.В. и соавт. Бактериальный вагиноз. Пособие для врачей. Москва; 2001.
-
2.
National Guideline for the Management of bacterial Vaginosis (2006). Clinical Effectiveness Group. British Association for Sexual Health and HIV. Available from: http://www.bashh.org/guidelines/2006/bv_final_0706.pdf
-
3.
Ralph S.G., Rutherford A.J., Wilson J.D. Influence of bacterial vaginosis on conception and miscarriage in the first trimester: cohort study. BMJ 1999; 319:220-3.
-
4.
Nugent R.P., Krohn M.A., Hillier S.L. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol 1991; 29:297-301.
-
5.
Ison C.A., Hay P.E. Validation of a simplified grading of Gram stained vaginal smears for use in genitourinary medicine clinics. Sex Transm Infect 2002; 78:413-5.
-
6.
Sexually transmitted and other reproductive tract infections. World Health Organization; 2005.
-
7.
Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm. Rep. 2006; 55:1-94.
-
8.
Кубанова А.А., ред. Методические материалы по диагностике и лечению наиболее распространенных инфекций, передаваемых половым путем (ИППП), и заболеваний кожи. Протоколы ведения больных, лекарственные средства. Москва: ГЭОТАР–МЕД; 2003.
-
9.
Osborne N.G. Tinidazole. J of Gynecol Surg 2004, 20:71-3.
-
10.
Austin M.N., Meyn L.A., Hillier S.L. Susceptibility of vaginal bacteria to metronidazole and tinidazole. Anaerobe 2006; 12:227-30.
-
11.
Beigi R.H., Austin M.N., Meyn L.A., Krohn M.A., Hillier S.L. Antimicrobial resistance associated with the treatment of bacterial vaginosis. Am J Obstet Gynecol 2004; 191:1124-9.
-
12.
Mattila J., Männistö P.T., Mäntylä R., Nykänen S., Lamminsivu U. Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route. Antimicrob Agents Chemother. 1983 May; 23:721–725.
-
13.
Nailor M.D., Sobel J.D. Tinidazole for bacterial vaginosis. Expert Rev Anti Infect Ther 2007; 5:343-8.
-
14.
Mohanty K.C., Deighton R. Comparison of 2 g single dose of metronidazole, nimorazole and tinidazole in the treatment of vaginitis associated with Gardnerella vaginalis. J Antimicrob Chemother 1987; 19:393-9.
-
15.
Schindler E.M., Thamm H., Ansmann E.B., Sarnow E., Schindler A.E. Treatment of bacterial vaginitis. Multicenter, randomized, open study with tinidazole in comparison with metronidazole. Fortschr Med 1991; 109:138-40.
-
16.
Milani M., Barcellona E., Agnello A. Efficacy of the combination of 2 g oral tinidazole and acidic buffering vaginal gel in comparison with vaginal clindamycin alone in bacterial vaginosis:a randomized, investigator-blinded, controlled trial. Eur J Obstet Gynecol Reprod Biol 2003; 109:67-71.
-
17.
Livengood C.H., Ferris D.G., Wiesenfeld H.C., Hillier S.L., Soper D.E., Nyirjesy P., et al. Effectiveness of two tinidazole regimens in treatment of bacterial vaginosis: a randomized controlled trial. Obstet Gynecol 2007; 110:302-9.