Clinical Microbiology and Antimicrobial Chemotherapy. 2006; 8(4):368-382
Beta-lactams remain the most used class of antibiotics all over the world. Among them, cephalosporins occupy the leading place. This is due to not only wide spectrum of activity, but also a good tolerability of this antibiotic class. Оral therapy with beta-lactams is an integral part of therapy of nosocomial community-acquired infections and step-down therapy of nosocomial infections. This review presents clinical and pharmacological properties of the oral III generation cephalosporin, ceftibuten, and an attempt to determine its place in the modern therapy of different infections.