Drug Therapy of Acute Otitis Media in Adult Outpatients: Results of the Multicenter Pharmacoepidemiological Study | CMAC

Drug Therapy of Acute Otitis Media in Adult Outpatients: Results of the Multicenter Pharmacoepidemiological Study

Clinical Microbiology and Antimicrobial Chemotherapy. 2004; 6(2):124-132

​ Kozlov S.N., Rachina S.A., Egorova O.A., Gudkov I.V., Emelyanova L.A., Dmitrenok O.V., Dobrovolskaya T.F., Karamysheva A.A., Kuzin V.B., Ortenberg E.A., Palyutin Sh.H., Tchemezov S.A., Stratchounski L.S.
acute otitis media аntimicrobial therapy pharmacoepidemiology
Section
Therapeutic Issues
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2004; 6(2):124-132

Abstract

Drug treatment of adult outpatients with acute otitis media (AOM) were analyzed. A total of 1489 case histo% ries of patients aged from 16 to 83 (55,6 ± 14,8) were included in the study from 8 Russian cities. The most frequently prescribed groups of drugs were antimicrobials for systemic use (79,7%), otologicals (61,3%), antihistamines (44,1%), nasal preparations (37,5%), throat preparations (23,5%), and antimicrobials for local use (22,3%). The most common antimicrobials prescribed were аmpicillin (17,6%), doxycycline (16,7%), аmoxicillin (15,3%), and ciprofloxacin (10,4%). Mono% therapy with antimicrobials was used in 93,6% of cases, and their combinations in 6,4% of cases. Two courses of antimicrobial therapy were prescribed to 4,6% of patients. The study has shown significant shortcomings of cur% rent approaches to drug therapy for AOM: inappropriate choice of antimicrobials, the use of potentially toxic drugs, use of medications with unproven clinical efficacy.

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