Role of Helicobacter pylori in Human Pathology | CMAC

Role of Helicobacter pylori in Human Pathology

Clinical Microbiology and Antimicrobial Chemotherapy. 2002; 4(2):128-145

Journal article


Helicobacter pylori is one of the most common pathogens in humans. H.pylori associated gastric diseases include chronic gastritis, gastric and duodenal peptic ulcer; moreover, role of this microorganism as a causative factor in the development of MALT-lymphoma and gastric cancer is also under consideration. This article presents microbiological properties of H.pylori and specific interactions between host and microorganism; molecular basis of pathogenicity are described. Local and systemic immune responses to the H.pylori infection are emphasized. Mechanisms of the development of gastric and duodenal peptic ulcer are discussed. The data, regarding the role of H.pylori as a risk factor for gastric cancer are reviewed.

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