Antimicrobials

Problem of Counterfeit Drugs: Focus on Antimicrobials

Clinical Microbiology and Antimicrobial Chemotherapy. 2005; 7(2):167-173

The problem of counterfeit drugs was first discussed at international level in 1985 at the World Health Organization Conference of Experts on the Rational Use of Drugs in Nairobi. Nowadays it is estimated that counterfeit arc up to 10% of allmarketed …

The Use of Antimicrobials in Pregnancy

Clinical Microbiology and Antimicrobial Chemotherapy. 2005; 7(1):77-91

The use of antimicrobials in pregnancy is associated with a potential risk for deleterious effect on fetus and neonate. Pregnancy may be associated with changes in pharmacokinetics because of reduced renal blood flow and glomerular filtration, …

Quinolones in Childhood and Pregnancy. Is There a Rationale for Their Use?

Clinical Microbiology and Antimicrobial Chemotherapy.2004; 6(4):377-393

The usage of quinolones and fluoroquinolones (FQ) in children and adolescents as well as in pregnant women is considered in this paper. Based on joint toxicity of FQ observed in immature animals this class of antimicrobial agents is officially …

New Approaches to the Treatment of Serious Bacterial Infections: Cefepime in Paediatric Practice

Clinical Microbiology and Antimicrobial Chemotherapy.2004; 6(4):371-376

Proceedings of the satellite symposium in the framework of the annual meeting of German Society for Pediatric Infectious Diseases, 3 Jun 2004, Mainz, Germany Chemotherapie Journal 2004; 13(Suppl 27):1-4.

Levofloxacin: Broadening of Indications

Clinical Microbiology and Antimicrobial Chemotherapy.2004; 6(3):282-285

Pharmaceutical Quality of Ceftriaxone Generic Drug Products Compared with Rocephin®

Clinical Microbiology and Antimicrobial Chemotherapy.2004; 6(3):260-272

Translated and reprinted with permission from “Journal of Chemotherapy” 2003; 15:357-68

The pharmaceutical qualities of 34 ceftriaxone generic products were compared with Rocephin as the reference standard.Quality standards specified in the European …

Continuous Infusion of β-Lactam Antibiotics as an Alternative to Conventional Methods of Administration

Clinical Microbiology and Antimicrobial Chemotherapy. 2004; 6(1):32-50

In vitro studies and animal models have shown that clinical efficacy of β-lactams depends on the duration of time plasma drug concentration needed to exceed the minimal inhibitory concentration for causative microorganism (time above MIC). In …

New Approaches to the Optimization of Antimicrobial Therapy of Respiratory Tract Infections Using Pharmacokinetic and Pharmacodynamic Parameters

Clinical Microbiology and Antimicrobial Chemotherapy. 2004; 6(1):22-31

To understand the relationship between drug dose and efficacy, pharmacokinetic (PK) and pharmacodynamic (PD) characteristics need to be integrated. There are two patterns of antimicrobial activity: time-dependent killing and concentration-dependent …

Antiretroviral drugs

Clinical Microbiology and Antimicrobial Chemotherapy. 2003; 5(4):360-379

Antiretroviral drugs today are the basis of HIV therapy. The severe and progressive nature of the disease and the need for lifelong therapy make the correct choice of drugs for HIV therapy of particular importance. Alarge number of antiretroviral …

Prophylactic and Empirical Use of Antifungals in Neonates

Clinical Microbiology and Antimicrobial Chemotherapy. 2003; 5(4):354-359

The aim of this study was to review published data on efficacy and safety of prophylaxis and empirical therapy with antifungals in neonates. We have found 37 reports on use of antimycotics in neonates, which had been published by June 2003. Of 37 …