Antimicrobials

Currently, prophylactic and therapeutic use of probiotics is a common practice worldwide, although their effectiveness remains controversial. This review presents data on main probiotic microorganisms. This paper summarizes available evidence-based …

Discovery and introduction into the clinical practice of macrolide antibiotics is one of the major advances in the history of antimicrobial therapy. The most prescribed macrolide is azithromycin, which is due to a number of its unique pharmacokinetic …

At present, β-lactams are the most commonly used antimicrobials, but their clinical efficacy may be reduced because of the spread of antimicrobial resistance. The most important mechanism of resistance to β-lactams is an inhibition by the microbial …

Clarithromycin – 14-membered macrolide antibiotic that has been used in clinical practice since 1991. This review presents up-to-date data on pharmacokinetics, pharmacodynamics, drug interactions, safety profile of clarithromycin, including its novel …

Translated and Reprinted with permission from «Chemotherapy Journal» (Chemother J. 2005; 14:22-27)

Spiramycin is classic representative of the 16-membered macrolides, which was synthesized in 1954. Nevertheless he keeps his clinical significance due to the high activity against typical causative agents of respiratory tract, skin and soft tissues …

In the treatment of uncomplicated urinary tract infec-tions the following groups of antimicrobial are of clinical use: fluoroquinolones, trimethoprim/sulfamethoxazole, nitrofurantoin, fosfomycin (one dose). In uncomplicated acute cystitis the short …

Urinary tract infections are one of the most prevalent community-acquired diseases. One of the crucial moments in the therapy of these infections is the usage of antibacterial drugs. This article shows the results of systematic review the goal of …

The problem of counterfeit drugs was first discussed at international level in 1985 at the World Health Organization Conference of Experts on the Rational Use of Drugs in Nairobi. Nowadays it is estimated that counterfeit arc up to 10% of allmarketed …

The use of antimicrobials in pregnancy is associated with a potential risk for deleterious effect on fetus and neonate. Pregnancy may be associated with changes in pharmacokinetics because of reduced renal blood flow and glomerular filtration, …