Antimicrobials

The aim of this study was to assess clinical efficacy of topical chloramphenicol in comparison to topical mupirocin in the treatment of mild to moderate communityacquired skin and soft tissue infections (SSTI). A total of 150 adult immunocompetent …

Multicenter prospective non-comparative open-label clinical study to assess clinical and microbiological efficacy and safety of josamycin (16-memebered macrolide) in adults with non-severe community-acquired pneumonia (CAP) was performed. Patients …

Beta-lactams remain the most used class of antibiotics all over the world. Among them, cephalosporins occupy the leading place. This is due to not only wide spectrum of activity, but also a good tolerability of this antibiotic class. Оral therapy …

Two groups of children on therapy with monofluoroquinolones were enrolled in this open trial: 169 patients with cystic fibrosis (exacerbation period) and 55 patients with aplastic anemia (neutropenic phase); age was from 6 months to 16 years. The aim …

Azithromycin is one of the most commonly used macrolides in the treatment of respiratory tract infections. Azithromycin is a popular antimicrobial due to a number of its unique pharmacokinetic and pharmacodynamic properties. This review describes the …

Carpabenems (imipenem, meropenem, ertapenem) are currently one of the antibiotic classes that exhibit the broadest spectrum of activity and characterized by the low resistance rates of clinically significant pathogens. This article is an attempt to …

Very-low-birth weight preterm infants (<1500 g) are at high risk for invasive candidiasis. The prospective randomized controlled clinical trial comparing efficacy of 2 doses of fluconazole (3 and 6 mg/kg) in the prophylaxis of invasive candidiasis …

Gemifloxacin is a new respiratory fluoroquinolone that was approved as Factive® in Russian Federation in December 2005. Among the fluoroquinolones this agent is the most active against Streptococcus pneumoniae, and has similar to other respiratory …

To compare the pharmacodynamics of daptomycin (DAP) and vancomycin (VAN) as well as killing kinetics of S. aureus with different MICs were studied at widely ranged AUC/MIC ratios. Two clinical isolates, S. aureus 866 (MICDAP 0.35 µ/ml and MICVAN 0.70 …

Beta-lactams are the most commonly used class of antimicrobial agents for the treatment of community-acquired and nosocomial infections. One of the resistance mechanisms for this class is a production of beta-lactamases. To overcome this problem, the …