Antimicrobials

The carbapenems are one of the most important classes of antimicrobial agents with an exceptionally broad spectrum of in vitro activity in association with low toxicity and beneficial pharmacokinetic parameters. Spectrum of activity of imipenem, …

Invasive aspergillosis remains as a frequent cause of lethality in hematological patients. The authors retrospectively analyzed the experience of caspofungin usage in 20 hematological patients with invasive aspergillosis in different medical centers …

Invasive fungal infections are still a growing problem of modern medicine. The prevalence of invasive fungal infections significantly increased during the last few decades concurrently with the increasing number of immunocompromised patients. The …

Macrolides are widely used antibiotics in a variety of infections, especially community-aquired. The clinical success of macrolides is due to their activity against classical causative agents, intracellular pathogens, and some protozoa. Of great …

The aim of this study was to assess clinical efficacy of topical chloramphenicol in comparison to topical mupirocin in the treatment of mild to moderate communityacquired skin and soft tissue infections (SSTI). A total of 150 adult immunocompetent …

Multicenter prospective non-comparative open-label clinical study to assess clinical and microbiological efficacy and safety of josamycin (16-memebered macrolide) in adults with non-severe community-acquired pneumonia (CAP) was performed. Patients …

Beta-lactams remain the most used class of antibiotics all over the world. Among them, cephalosporins occupy the leading place. This is due to not only wide spectrum of activity, but also a good tolerability of this antibiotic class. Оral therapy …

Two groups of children on therapy with monofluoroquinolones were enrolled in this open trial: 169 patients with cystic fibrosis (exacerbation period) and 55 patients with aplastic anemia (neutropenic phase); age was from 6 months to 16 years. The aim …

Azithromycin is one of the most commonly used macrolides in the treatment of respiratory tract infections. Azithromycin is a popular antimicrobial due to a number of its unique pharmacokinetic and pharmacodynamic properties. This review describes the …