Antimicrobials

Carbapenems are the most appropriate antimicrobials for empiric and pathogen-directed monotherapy in most severe and life-threatening infections in pediatric patients. It can be explained by broadest spectrum of activity, including multidrug …

Cefixime is the first oral 3-rd generation cephalosporin. This antimicrobial agent has good oral bioavailability (40-50%); Cmax in blood (2.6-4.8 mg/I)is achieved in 4 hours after single oral dose, maximal tissue concentration - in 6.7 hours. …

The susceptibility to aminoglycoside antimicrobials of Gram-negative nosocomial pathogens in Russia and mechanisms of aminoglycoside resistance has been studied. The production of aminoglycoside-modifying enzymes remains to be the major mechanism of …

There is a clinical need for newer effective antimicrobials that would overcome resistance mechanisms across a wide range of microorganisms. Doripenem is a novel promising carbapenem antimicrobial, which was approved by Food and Drug Administration …

Bacterial vaginosis is a common disease of female genital tract. It is characterised by substitution of lactobacteriae, which are predominant part of normal vaginal flora, with Gardnerella vaginalis and anaerobes, and has serious social and medical …

Translated and reprinted with permission from «Chemotherapie Journal» 2007; 16:41-8.

The main objective of this study was to compare the efficacy of levofloxacin in hospitalized patients suffering from pneumonia to other antibiotic options by …

In spite of development of number of new antimicrobials of other classes, aminoglycosides are still widely used in clinical practice. Their rapid bactericidal activity against the majority of common human pathogens as well as synergism with some …

The carbapenems are one of the most important classes of antimicrobial agents with an exceptionally broad spectrum of in vitro activity in association with low toxicity and beneficial pharmacokinetic parameters. Spectrum of activity of imipenem, …

Invasive aspergillosis remains as a frequent cause of lethality in hematological patients. The authors retrospectively analyzed the experience of caspofungin usage in 20 hematological patients with invasive aspergillosis in different medical centers …