Antimicrobials

Piperacillin/tazobactam, penicillin/beta-lactamase inhibitor combination, has a broad antimicrobial spectrum, including most gram-positive cocci and gram-negativeaerobic and anaerobic bacteria (including beta-lactamase producing microorganisms). …

Spiramycin, natural 16-membered macrolide antibiotic, was discovered in 1954. This antimicrobial agent is at least non-inferior to and has some advantages over the currently available macrolides in spectrum of activity, pharmacological properties, …

The present article describes comparative pharmacokinetic study of different generic oral forms of amoxicillin — soluble tablets «Flemoxin Solutab», manufactured by «Astellas Pharma Europe B.V.», Netherlands, and powder for suspension «Amosin», …

According to the mutant selection window (MSW) hypothesis resistant mutants are selected at antibiotic concentrations above the MIC but below the mutant prevention concentration (MPC). There are contradictory reports on the relationships between MIC- …

Telavancin (TLV) is an investigational lipoglycopeptide with multiple mechanism of action. It exhibits rapid bactericidal activity against gram-positive bacteria, including methicillin-susceptible and -resistant, glycopeptide-intermediate and …

The carbapenems are class of beta-lactam antibiotics with exceptionally wide spectrum of activity, beneficial pharmacokinetic parameters and low toxicity as well. Such agents as imipenem and meropenem have already been succesfully used for a long …

Carbapenems are the most appropriate antimicrobials for empiric and pathogen-directed monotherapy in most severe and life-threatening infections in pediatric patients. It can be explained by broadest spectrum of activity, including multidrug …

Cefixime is the first oral 3-rd generation cephalosporin. This antimicrobial agent has good oral bioavailability (40-50%); Cmax in blood (2.6-4.8 mg/I)is achieved in 4 hours after single oral dose, maximal tissue concentration - in 6.7 hours. …

The susceptibility to aminoglycoside antimicrobials of Gram-negative nosocomial pathogens in Russia and mechanisms of aminoglycoside resistance has been studied. The production of aminoglycoside-modifying enzymes remains to be the major mechanism of …

There is a clinical need for newer effective antimicrobials that would overcome resistance mechanisms across a wide range of microorganisms. Doripenem is a novel promising carbapenem antimicrobial, which was approved by Food and Drug Administration …