Аннотация
Аминогликозиды относятся к одному из важнейших классов антимикробных препаратов и, несмотря на наличие объективных недостатков, связанных с относительно высокой частотой специфических нежелательных реакций, остаются актуальными и востребованными в терапии ряда инфекций. Тобрамицин является типичным представителем аминогликозидов, при этом обладая хорошим профилем безопасности и более выраженной активностью в отношении Pseudomonas aeruginosa — «проблемного» возбудителя тяжелых инфекций, часто нозокомиальной природы. Последнее обстоятельство, с учетом особенностей формирования антибиотикоустойчивости патогена, и определяет область его применения в современной клинической практике. В обзоре представлены фармакокинетические и фармакодинамические характеристики тобрамицина, а также приведены результаты качественных клинических исследований, демонстрирующих эффективность его использования в комбинации с другими антибиотиками при жизнеугрожающих инфекциях синегнойной этиологии. В данной статье не рассматриваются вопросы ингаляционного применения тобрамицина как возможной основы лечения у пациентов с муковисцидозом.
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