Аннотация
Первоначально внутривенные иммуноглобулины (ВВИГ) применялись в качестве заместительной терапии при лечении больных с врождёнными иммунодефицитами, протекающими с поражением гуморального звена иммунной системы. В дальнейшем ВВИГ начали с успехом использовать в комплексной терапии системных и аутоиммунных заболеваний. Несмотря на широкое применение, исследователи не пришли к единому мнению о механизмах действия ВВИГ. Имеются данные, что клинический эффект ВВИГ достигается в результате: 1) блокады Fcγ рецепторов; 2) предотвращения активации белков системы комплемента; 3) нейтрализации суперантигенов; 4) регуляции секреции цитокинов; 5) антиидиотипических взаимодействий. Большинство препаратов ВВИГ не вызывают активации комплемента и поэтому хорошо переносятся пациентами, но иногда могут индуцировать нежелательные лекарственные реакции (НЛР), что, вероятно, связано с другими механизмами действия. В этом обзоре рассматриваются различные механизмы действия ВВИГ, а также возможные причины развития НЛР.
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