Intravenous Immunoglobulins: Mechanisms of Action and Possible Clinical Applications

Clinical Microbiology and Antimicrobial Chemotherapy.2004; 6(3):273-281

​ Avertchenkov V.M., Palagin I.S.
intravenous immunoglobulins mechanisms of action indications side effects
Section
Therapeutic Issues
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy.2004; 6(3):273-281

Abstract

Historically, intravenous immunoglobulins (ivIg) were initially used as replacement therapy in patients with antibody deficiency disorders.Later on ivIg were suggested to have advantages in treatment of patients with autoimmune and systemic inflammatory diseases.Different mechanisms of ivIg activity have been proposed, such as neutralization of superantigens, inhibition of complement deposition, Fcγ receptor blockade, etc.The data on possible side effects of ivIg and its suggested mechanisms are also presented.

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