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Functional and antigenspecific serum antibodies in mice after immunization with a candidate vaccine against Shigella flexneri 1b, 2a, 3a, 6, Y

Objective. To determine functional anti-LPS specific serum bactericidal antibody (SBA) and opsonophagocytic killing antibody (OPKA) activities in mice immunized with a pentavalent candidate vaccine against Shigella flexneri 1b, 2a, 3a, 6, Y (PF). Materials and Methods. (CBA x C57 B1/6) F1 mice were immunized with a PF. 14 days after the reimmunization, serum samples were collected and the level of specific IgG in them was determined by ELISA. The sera of mice immunized with individual modified lipopolysaccharides (mLPS), which are part of PF, were used for positive control.

Development of vaccines against gonorrhoea, syphilis, chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus

The success in preventing hepatitis B virus and human papillomavirus infections by means of vaccination paves the way for the development of other vaccines to prevent sexually transmitted infections (STIs) such as gonorrhoea, syphilis, chlamydia, …

Serological Characteristics and Antimicrobial Susceptibility of Streptococcus pneumoniae Isolated from Children Under 5 Years and Patients >65 Years in Belarus and Ukraine

Objective. Objectives. To reveal serotypes of Streptococcus pneumoniaе isolated from patients with pneumococcal infections and from healthy carriers in Belarus and Ukraine. Materials and Methods. There were 314 strains of S. pneumoniae in this investigation, from patients and asymptomatic carriers at the age from 0 to 90 years. After re-identification and susceptibility testing to penicillin, serogroup and serotype was identified for each strain. Using this data the coverage of 7-, 10- and 13-vallent pneumococcal conjugate vaccines was determined.