sulbactam

Despite the presence of more than 100 different antibacterials in the therapeutic arsenal, beta-lactam antibiotics, in general, and the third-generation cephalosporins, in particular, remain the main option for the treatment of the most of infections …

The recently approved cefotaxime/sulbactam, combination of third-generation cephalosporin (cefotaxime) and beta-lactamase inhibitor (sulbactam), can combat resistance mechanisms associated with the production of serine beta-lactamases, including some …

At present, β-lactams are the most commonly used antimicrobials, but their clinical efficacy may be reduced because of the spread of antimicrobial resistance. The most important mechanism of resistance to β-lactams is an inhibition by the microbial …