Clinical Microbiology and Antimicrobial Chemotherapy. 2025; 27(2):258-264
Objective. To compare antibacterial activity of macrocidins A and Z against staphylococci and their effect on staphylococcal biofilms.
Materials and Methods. The antibacterial activity of macrocidins A and Z produced by Didymella baileyae VIZR 1.53 was studied by serial dilution method against 120 staphylococcal cultures isolated from orthopedic patients. The effect of macrocidins on biofilm formation of 60 S. aureus clinical cultures was assessed by O’Toole method by co-incubation of active substances with bacteria and subsequent MBIC50/90.