Levofloxacin Efficacy – the Success Predictors

Objective. Aim. To evaluate the comparable solubility of original levofloxacin (Tavanic, Sanofi–Aventis, France) and its generics. Materials and Methods. The resolution kinetics of the original drug and two generics was studied in different рН levels. The choice of рН levels was done according to the US pharmacopeia. Results. The original levofloxacin has shown the stable parameters important for bioavailability independently from рН level. At the same time resolution kinetics of two generic products significantly varied depending on рН.

Quality of Generic Drug Products and Equivalence to Original Drug Products

Generic drugs account for 78 to 95% of drug products on the Russian pharmaceutical market and represent a common way of decreasing treatment cost. The main problem of generic drugs is a pharmaceutical quality and comparability between generic and …