periprosthetic joint infection

Objective. To assess impact of the COVID-19 pandemic on the structure of pathogens causing periprosthetic joint infection (PJI) and the dynamics of their antibiotic resistance. Materials and Methods. A retrospective analysis of 379 strains of microorganisms isolated from patients with PJI of the knee and hip joints who underwent surgical treatment at the Federal Center for Traumatology and Orthopedics from 2018 to 2024 was performed. The biological material for the study was synovial fluid samples, tissue biopsies, aspirates from removed implants after ultrasonic treatment.

Objective. To characterize periprosthetic joint infection in patients undergoing a total hip and knee joint replacement. Materials and Methods. A total of 77 patients with periprosthetic infection following hip and knee joint replacement hospitalized in Grodno City Clinical Hospital were studied over the period of 2014-2018. Wound discharge, tissue samples, and fistula’s wall swab were used for microbiological tests. The analysis of surgical treatment of patients with deep periprosthetic knee and hip joint infection has been performed.

Objective. To assess a potential for the use of fosfomycin as a component of polymethyl methacrylate-based bone cement in the topical treatment of periprosthetic infection. Materials and Methods. The most common pathogens of periprosthetic joint infection isolated during the 2013–2014 were studied. Susceptibility of 358 S. aureus and 19 E. coli strains to vancomycin, fosfomycin, and gentamicin was determined. Antimicrobial activity duration for the control samples of the gentamicin-containing bone cement (DEPUY CMW 1 GENTAMICIN) and the experimental samples with addition (per 20 g of cement) of 1 g or 2 g of vancomycin (5% or 10%), 2 g or 4 g of fosfomycin (10% or 20%) was investigated.