Comparative Efficacy of Topical Combination of Bacitracin and Neomycin vs. Chloramphenicol in the Treatment of Uncomplicated Mild to Moderate Surgical Skin and Soft Tissue Infections in Adult Out-patients

Objective. To assess clinical efficacy and safety of topical combination of bacitracin and neomycin in comparison to topical chloramphenicol in the treatment of uncomplicated mild to moderate surgical skin and soft tissue infections (SSTI) in adult out-patients. Materials and Methods. A total of 309 adult patients with mild to moderate SSSTI were randomized to receive either topical powder and/or ointment of bacitracin+neomycin (n=156) or topical 0.75% chloramphenicol ointment (n=153) BID.