microbiological diagnostics

Experience in creating a closed digital loop for continuous antimicrobial resistance surveillance based on validated microbiological test results

Clinical Microbiology and Antimicrobial Chemotherapy. 2025; 27(3):369-389

10.36488/cmac.2025.3.369-389

Objective. To implement a closed digital loop for continuous antimicrobial resistance (AMR) surveillance based on validated microbiological diagnostic results. Materials and Methods. A prospective study was conducted at the Federal State Autonomous Institution «National Medical Research Center for Treatment and Rehabilitation» of the Ministry of Health of the Russian Federation from May 2024 to September 2025. An audit of the initial state of processes, a SWOT analysis, software restructuring, data flow optimization and standardization of diagnostic methods in accordance with EUCAST recommendations were performed.

β-Lactamases of Aerobic Gram-Negative Bacteria: Description, Principles of Classification, Methods of Detection and Typing

Clinical Microbiology and Antimicrobial Chemotherapy. 2001; 3(3):223-242

β-Lactamases are represented by extensive range of genetically and functionally different enzymes that are able to destroy β-lactams that leads to development of resistance to these antibiotics in β-lactamases producing bacteria. Intrinsic production …

Detection of Extended Spectrum β-lactamases by Phenotypic Methods in Gram-negative Bacteria

Clinical Microbiology and Antimicrobial Chemotherapy. 2001; 3(2):183-189

Production of extended-spectrum β-lactamases (ESBL) is the one of most widespread and clinically significant mechanism of resistance to modern β-lactams in members of the family Enterobacteriaceae. But the effectiveness of routine methods of …