Clinical Microbiology and Antimicrobial Chemotherapy. 2010; 12(4):347-352
Objective. Objective: To investigate antagonistic activity of multicomponent probiotic products resulting from interactions of microorganisms; to develop bacterial selection criteria for multi-component biological products.
Materials and Methods. Culture fluid of the paired probiotic strain associations: Bifidobacterium longum with Enterococcus faecium («Bifiform» product), Escherichia coli M-17 («Colibacterin» product) and Lactobacillus plantarum 8РА-3 («Lactobacterin» product) were tested for bactericidal activity against Staphylococcus aureus. Also, culture fluid of the each strain was treated with metabolites and peptidoglycan of the associative species and then tested for bactericidal activity against Staphylococcus aureus.