metallo-beta-lactamases

Objective. To characterize the population structure and determine the genetic mechanisms of carbapenem resistance in nosocomial isolates of P. aeruginosa collected in Moscow in 2012-2016. Materials and methods. Carbapenem-resistant isolates were collected in two pediatric hospitals in Moscow. Antibiotics susceptibility of P. aeruginosa isolates was assessed using the E-tests and disk-diffusion method. Multilocus sequence typing (MLST) was used for genotyping of the isolates. The presence of metallo-betalactamase (MBL) genes was determined using real-time PCR.

Incidence rates of Acinetobacter spp. isolated from tissue specimens and wound samples in patients with severe burns, chronic osteomyelitis, and diabetic foot infections were determined during the 5 years (2008– 2012). Antimicrobial resistance of …