Objective. To select an optimal (in terms of influence on the antibiotic resistance level) and cost-effective structure of antibiotic consumption in a hospital in the management of patients with acute uncomplicated pyelonephritis.
Materials and Methods. Based on the literature data as well as a real practice of antibiotic administration, the cost of treatment of an acute uncomplicated pyelonephritis case with different regimens of initial antimicrobial treatment was calculated. Using mathematical modeling, changes in antimicrobial resistance of E.