linezolid

Objective. To study pharmacokinetics (PK) and develop a pharmacokinetic/pharmacodynamic (PK/PD) model of linezolid for preterm infants, based on therapeutic drug monitoring (TDM) data. Materials and Methods. The PK/PD analysis included data from therapeutic drug monitoring (TDM) of 24 premature infants, taking into account the repeated TDM procedure – a total of 27 occasions and 54 measurements of linezolid concentration. Quantitative determination of linezolid concentrations in the blood plasma of patients was carried out using the analytical method of measurement by HPLC-UV previously developed on the basis of the educational and scientific laboratory for the study of drug safety at the Department of General and Clinical Pharmacology of the RUDN University in the City Clinical Hospital No.

Objective. To determine frequency of Staphylococcus isolation and antimicrobial resistance in hospitalized children with different types of infections. Materials and Methods. Species identification and antimicrobial susceptibility testing in staphylococci were performed on a WalkAway 96 analyzer using Pos Combo type 20 tablets, and mecA gene detection was performed on a RotorGene 6000 amplifier with a set of AmpliSens MRSA-screen FL. Results. A total of 876 strains of staphylococci isolated in children’s hospitals were tested.

Tedizolid is a novel oxazolidinone that has been recently approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) caused by Gram-positive pathogens, including MRSA. The mechanism of action of tedizolid is similar to …

The recent approaches to the treatment of endocarditis caused by Enterococcus spp., including strains that are resistant to conventional therapy, are discussed in the article. The possible ways of reduction of nephrotoxicity in elder patients and in …

Objective. To determine in vitro activity of antimicrobials against S. aureus isolated from hospitalized patients from different regions of Russia. Materials and Methods. A total of 879 clinical strains of S. aureus isolated in 2000–2001 from patients hospitalized in 17medical institutions in different parts of Russia. Susceptibility to 18 antimicrobials: oxacillin, vancomycin, teicoplanin, linezolid, erythromycin, clindamycin, lincomycin, gentamicin, mupirocin, fusidic acid, ciprofloxacin, levofloxacin, moxifloxacin, quinupristin/dalfopristin, rifampicin, trimethoprim/sulfamethoxazole, tetracycline, chloramphenicol was determined by agar dilution method in accordance with the NCCLS recommendations.