invasive fungal infections

The current place of echinocandins in the treatment and prophylaxis of invasive fungal infections

Invasive fungal infections continue to show steady growth among various patient populations, accompanied by high rates of both morbidity and attributive mortality. For the treatment of invasive mycoses, a few number of drugs are currently available, …

The tablet formulation of posaconazole: clinical pharmacology and the use in patients with hematologic malignancies

Posaconazole is a broad-spectrum triazole antifungal agent with potent activity against various fungi, including yeast and molds, including Mucorales, what makes a key difference with itraconazole and voriconazole. Clinical studies have demonstrated …

New Drug Formulations of Posaconazole: Brief Clinical Pharmacology Review

Posaconazole is a second generation triazole with a broad spectrum of activity, which first appeared on the market in 2005 in the form of a suspension for oral administration. Despite some progress made in the framework of clinical trials, the …

Systemic Antimycotics: Key Aspects and Perspectives

Invasive fungal infections are still a growing problem of modern medicine. The prevalence of invasive fungal infections significantly increased during the last few decades concurrently with the increasing number of immunocompromised patients. The …

Efficacy and Safety of Caspofungin in Children with Invasive Fungal Infections

The prospective study of 19 children (aged of 1 to 17 years) with invasive fungal infections and different forms of immunosupression was conducted. Clinical and microbiological efficacy and safety of caspofungin, as well as analysis of direct costs …