infection

Objective. To study the prevalence and mechanisms of antibiotic resistance, including carbapenemase production, in clinical isolates of Klebsiella pneumoniae and Escherichia coli isolated in different regions of Russia as part of the sentinel multicenter surveillance study in 2020–2021, and to explore the population structure of K. pneumoniae and the impact of “high-risk clones” on antibiotic resistance. Materials and Methods. Consecutive, non-duplicate isolates of K. pneumoniae (n = 2503) and E.

This review aims to describe the microbiological characteristics, resistant features and pathogenic potential of Achromobacter spp. Achromobacter as an opportunistic pathogen can cause severe and even fatal infections. The current knowledge about …

This article is an overview of the data on bacterial intestinal translocation. The article reviews changes in the intestinal microbiome, the local physiological barrier, as well as the innate and adaptive immunity characteristics contributing to the …

Objective. To compare the Quick Sequential (Sepsis-Related Organ Failure Assessment (qSOFA), National Early Warning Score (NEWS) and Systemic Inflammatory Response Syndrome (SIRS) scores value in predicting poor outcomes in emergency department patients with/without infection in Russia. Materials and Methods. This prospective observational study included data from 270 patients, of whom 132 (48.8%) patients had an infection and 138 (51.2%) did not have an infection. Comparison of areas under the ROC-curves (Receiver Operating Characteristic Curve) for the qSOFA, NEWS and SIRS scores in predicting the composite outcome (death and/or length of intensive care unit stay >1 day) was performed.

One of the most common problems in neonatal hospitals is the choice of metrics of drugs usage in neonatology, especially use of antibiotics. This study represents our experience in quantifying antibiotic use in a Level-III neonatal intensive care …

Epidemiological data on the prevalence of infections in ICU is crucial for clinical practice. At the same time in Russia only very limited local information was available. So, the aim of the present study was to evaluate the prevalence and etiology …

Chronic prostatitis/chronic pelvic pain syndrome is one of the most common diseases in urology which is difficult to diagnose and treat. According to current international guidelines, choice of approach to the management of patients with chronic …

Reproduced with permission from the Society of Critical Care Medicine, the European Society of Intensive Care and Medicine and the International Sepsis Forum.

The combination of ceftazidime with an aminoglycoside is a commonly used standard for empiric therapy of febrile neutropenia. A lot of attention is paid to the development of effective monotherapy for the treatment of this condition. One of the most …