Gram-negative bacteria

Ceftazidime-avibactam: new rules for the game against multidrug-resistant gram-negative bacteria

The rapid spread of multidrug-resistant Gram-negative bacteria in hospital settings all over the world makes a demand for the new options to overcome antimicrobial resistance. Ceftazidime-avibactam is the first approved antibiotic that contains a new …

Carbapenemase-producing Gram-negative bacteria in the Russian research center of radiology and surgical technologies

Objective. To assess an incidence rate of carbapenemase-producing Gram-negative bacteria isolated from patients in the RRCRST. Materials and Methods. The clinical Gram-negative isolates obtained from patients hospitalized to the RRCRST over the period of February 2014 to April 2016 were tested. A screening for carbapenem resistance was performed by culture on chromogenic media, and species identification was made using MALDI-TOF massspectrometry. Susceptibility of Gram-negative bacteria to antimicrobial agents was determined using VITEK-2.

β-Lactamases of Aerobic Gram-Negative Bacteria: Description, Principles of Classification, Methods of Detection and Typing

β-Lactamases are represented by extensive range of genetically and functionally different enzymes that are able to destroy β-lactams that leads to development of resistance to these antibiotics in β-lactamases producing bacteria. Intrinsic production …

Detection of Extended Spectrum β-lactamases by Phenotypic Methods in Gram-negative Bacteria

Production of extended-spectrum β-lactamases (ESBL) is the one of most widespread and clinically significant mechanism of resistance to modern β-lactams in members of the family Enterobacteriaceae. But the effectiveness of routine methods of …