dynamic in vitro systems

Objective. Introduction. Selective digestive decontamination of the digestive tract (SDD) with non-absorbable antibiotics is considered a promising approach to reduce the risk of infections in critically ill patients. However, the widespread circulation of multidrug-resistant microorganisms, including carbapenemresistant Klebsiella pneumoniae and Pseudomonas aeruginosa, significantly reduces the efficacy of conventional SDD regimens based on colistin monotherapy. The key reason for failures is the wide «mutant selection window» – a range of antibiotic concentrations insufficient to suppress the growth of resistant subpopulations.