drug resistance

Objective. To study molecular and genetic features of M. tuberculosis (MTB) and human immunodeficiency virus (HIV) in patients with unfavorable course of HIV infection and tuberculosis. Materials and Methods. A total of 105 patients with HIV infection and newly diagnosed tuberculosis in whom tuberculosis was confirmed by microbiological and molecular genetic methods were included. The follow-up period was at least 6 months. Based on the results of the examination during treatment, all patients were divided into two groups: group 1 – patients with favorable course of HIV infection and tuberculosis (n = 78), group 2 – patients with unfavorable course of HIV infection and tuberculosis (n = 27).

Objective. To identify point mutations in 23S rRNA gene associated with phenotypic drug resistance to clarithromycin (CLR) in clinical isolates of H. pylori. Materials and Methods. A total of 50 H. pylori clinical isolates (2014–2022) from adult patients with chronic gastritis (n = 32), duodenal ulcer (n = 11) and gastric cancer (n = 1) were included in this study. Of 50 isolates, 30 were obtained from newly diagnosed patients, 20 – from previously treated patients after eradication failure.

Rapid tests detecting Mycobacterium tuberculosis and drug resistance which are universally implemented in medical practice has dramatically improved the diagnosis of rifampicin-resistant tuberculosis and shortened turnaround time thus enabling early …

Susceptibility to antibiotics was determined for 208 hospital isolates from 4 regions of Belarus. The broad abundance of resistance to carbapenems was shown. The genes of carbapenemases blaNDM, blaOXA-48 and blaKPC were detected in 55 strains from 12 …