cystic fibrosis

Objective. To study the population and genetic structure of S. pneumoniae isolated from children with cystic fibrosis (CF) and congenital malformations of the bronchi and lungs (CM) over the period 2011 to 2021, their serotype diversity in pre-vaccination and post-vaccination periods and susceptibility to antimicrobials. Materials and Methods. A total of 140 S. pneumoniae isolates (during 2011-2021) from respiratory samples of patients with CM or CF were included in the study.

Objective. To evaluate the results of implementing the AMRcf and AMRcloud platforms for microbiological surveillance studies of patients with cystic fibrosis (CF) into the routine practice of a microbiological laboratory. Materials and Methods. The study was performed on the basis of the Department of Microbiology of the Clinical diagnostic laboratory of the Clinics of the Samara State Medical University. To perform the study, the following computer programs were introduced into routine practice: AMRcf (online microbiological registry for CF patients) and AMRcloud (online platform for analysis of collected data on antibiotic resistance).

Objective. Analysis of the distribution of the values of the minimum inhibitory concentrations (MIC) of a number of antibacterial drugs in relation to representatives of the order Flavobacteriales isolated from respiratory samples from patients with cystic fibrosis of the Russian Federation by the method of double serial dilutions. Materials and Methods. The distribution of the values of MIC of a number of antibacterial drugs was evaluated in relation to 100 strains of bacteria, representatives of the order Flavobacteriales, isolated from respiratory samples from patients with cystic fibrosis from 60 regions of the Russian Federation as part of a routine microbiological examination.

Infectious complications in the respiratory tract caused by microorganisms from the Burkholderia cepacia complex are the main cause of death among patients with cystic fibrosis. Natural and acquired resistance mechanisms allow Burkholderia cepacia …

Objective. To determine species, sequence-types, antimicrobial resistance and virulence genes in Achromobacter spp. isolates obtained from cystic fibrosis (CF) patients in Russia. Materials and Methods. Samples (sputum, nasopharyngeal swab) from 168 CF patients from 48 regions were studied. Whole-genome sequencing (WGS) was performed on MGISEQ-2000 platform. SPAdes software, Galaxy, ResFinder, Integrall, PubMLST were used for analysis of WGS data. Results. A total of 18 strains of Achromobacter spp. were isolated from 16 of 168 CF patients.

Objective. To identify bacterial interactions at the site of infection in cystic fibrosis patients and to assess their possible effects on the course of infection. Materials and Methods. The following strains were used in this study: Alcaligenes faecalis LGBP strain, isolated from the environment; clinical isolates of Pseudomonas aeruginosa; Achromobacter xylosoxidans, Acinetobacter baumannii, Alcaligenes faecalis, and Bacillus subtilis strains; the standard laboratory P. aeruginosa PAO1 strain and its lysogens by temperate bacteriophages of various species, and its phageresistant mutants.

This paper represents a review of currently available date on potential new pathogen in patients with cystic fibrosis. Chronic microbial colonization of the respiratory tract, leading to exacerbations of pulmonary infection, is the major cause of …

The objective of this study was to develop algorithm of microbiological diagnosis for chronic lung infection in patients with cystic fibrosis and implement it for monitoring of chronic infection in children and adults. Data from our own studies …

Chronic airway inflammation and infection are the main cause of mortality in patients with cystic fibrosis (CF), therefore effective antimicrobial therapy is important part of treatment of CF-lung disease. In the article, an overview on present …

Two groups of children on therapy with monofluoroquinolones were enrolled in this open trial: 169 patients with cystic fibrosis (exacerbation period) and 55 patients with aplastic anemia (neutropenic phase); age was from 6 months to 16 years. The aim …