cystic fibrosis

Objective. Analysis of the distribution of the values of the minimum inhibitory concentrations (MIC) of a number of antibacterial drugs in relation to representatives of the order Flavobacteriales isolated from respiratory samples from patients with cystic fibrosis of the Russian Federation by the method of double serial dilutions. Materials and Methods. The distribution of the values of MIC of a number of antibacterial drugs was evaluated in relation to 100 strains of bacteria, representatives of the order Flavobacteriales, isolated from respiratory samples from patients with cystic fibrosis from 60 regions of the Russian Federation as part of a routine microbiological examination.

Infectious complications in the respiratory tract caused by microorganisms from the Burkholderia cepacia complex are the main cause of death among patients with cystic fibrosis. Natural and acquired resistance mechanisms allow Burkholderia cepacia …

Objective. To determine species, sequence-types, antimicrobial resistance and virulence genes in Achromobacter spp. isolates obtained from cystic fibrosis (CF) patients in Russia. Materials and Methods. Samples (sputum, nasopharyngeal swab) from 168 CF patients from 48 regions were studied. Whole-genome sequencing (WGS) was performed on MGISEQ-2000 platform. SPAdes software, Galaxy, ResFinder, Integrall, PubMLST were used for analysis of WGS data. Results. A total of 18 strains of Achromobacter spp. were isolated from 16 of 168 CF patients.

Objective. To identify bacterial interactions at the site of infection in cystic fibrosis patients and to assess their possible effects on the course of infection. Materials and Methods. The following strains were used in this study: Alcaligenes faecalis LGBP strain, isolated from the environment; clinical isolates of Pseudomonas aeruginosa; Achromobacter xylosoxidans, Acinetobacter baumannii, Alcaligenes faecalis, and Bacillus subtilis strains; the standard laboratory P. aeruginosa PAO1 strain and its lysogens by temperate bacteriophages of various species, and its phageresistant mutants.

This paper represents a review of currently available date on potential new pathogen in patients with cystic fibrosis. Chronic microbial colonization of the respiratory tract, leading to exacerbations of pulmonary infection, is the major cause of …

The objective of this study was to develop algorithm of microbiological diagnosis for chronic lung infection in patients with cystic fibrosis and implement it for monitoring of chronic infection in children and adults. Data from our own studies …

Chronic airway inflammation and infection are the main cause of mortality in patients with cystic fibrosis (CF), therefore effective antimicrobial therapy is important part of treatment of CF-lung disease. In the article, an overview on present …

Two groups of children on therapy with monofluoroquinolones were enrolled in this open trial: 169 patients with cystic fibrosis (exacerbation period) and 55 patients with aplastic anemia (neutropenic phase); age was from 6 months to 16 years. The aim …

Nonfermenting gram-negative rods (NGR) are one of the leading nosocomial pathogens. Among them Pseudomonas aeruginosa, Acinetobacter baumannii, Pseudomonas aeruginosa, Acinetobacter spp., Burkholderia spp., Stenotrophomonas spp., and Chryseobacterium …

The usage of quinolones and fluoroquinolones (FQ) in children and adolescents as well as in pregnant women is considered in this paper. Based on joint toxicity of FQ observed in immature animals this class of antimicrobial agents is officially …