In vitro activity of thiamphenicol against Haemophilus influenzae, Streptococcus pneumoniae and Streptococcus pyogenes clinical isolates

Objective. To determine in vitro activity of thiamphenicol and other clinically available antimicrobials against clinical isolates of Haemophilus influenzae, Streptococcus pneumoniae and Streptococcus pyogenes. Materials and Methods. We included in the study 875 clinical isolates from 20 Russian cities during 2018–2019. Among tested strains, 126 were H. influenzae, 389 – S. pneumoniae, 360 – S. pyogenes. Antimicrobial susceptibility testing was performed using broth microdilution method according to ISO 20776-1:2006. AST results were interpreted according to EUCAST v.

Comparative Efficacy of Topical Combination of Bacitracin and Neomycin vs. Chloramphenicol in the Treatment of Uncomplicated Mild to Moderate Surgical Skin and Soft Tissue Infections in Adult Out-patients

Objective. To assess clinical efficacy and safety of topical combination of bacitracin and neomycin in comparison to topical chloramphenicol in the treatment of uncomplicated mild to moderate surgical skin and soft tissue infections (SSTI) in adult out-patients. Materials and Methods. A total of 309 adult patients with mild to moderate SSSTI were randomized to receive either topical powder and/or ointment of bacitracin+neomycin (n=156) or topical 0.75% chloramphenicol ointment (n=153) BID.

Comparative Efficacy of 0.75% Chloramphenicol Ointment and 2% Mupirocin Ointment in the Treatment of Community-Acquired Skin and Soft Tissue Infections

The aim of this study was to assess clinical efficacy of topical chloramphenicol in comparison to topical mupirocin in the treatment of mild to moderate communityacquired skin and soft tissue infections (SSTI). A total of 150 adult immunocompetent …