cefixime

Cephalosporins are one of the most commonly used antimicrobials for the treatment of variety of bacterial infections. Prudent use of the third-generation cephalosporins is important for the control of spread of cephalosporin-resistant Gram-negative …

This paper presents current issues with the oral thirdgeneration cephalosporins in outpatient clinical practice. These data are based on the principles of appropriate antimicrobial therapy, national antimicrobial susceptibility data, and …

This paper describes a multicenter, randomized study to compare clinical and microbiological efficacy, and safety of azithromycin (Sumamed®, Teva) and cefixime (Suprax®, Gedeon-Richter) in the treatment of acute infectious invasive diarrhea in …

Objective. To evaluate clinico-economical effectiveness of short course of cefixime and ciprofloxacin in women with acute uncomplicated cystitis. Materials and Methods. A prospective randomized clinico-economic study of effectiveness of cefixime and ciprofloxacin in 104 patients with acute uncomplicated cystitis. Results. At visit 2 (day 8) microbiological cure rates were detected in 95.9%, 55.6% and 71.4% of patients from Group 1 (cefixime), Group 2-a (ciprofloxacin 250 mg BID) and Group 2-b (ciprofloxacin 500 mg BID), respectively.

Cefixime is the first oral 3-rd generation cephalosporin. This antimicrobial agent has good oral bioavailability (40-50%); Cmax in blood (2.6-4.8 mg/I)is achieved in 4 hours after single oral dose, maximal tissue concentration - in 6.7 hours. …