candidiasis

The current place of echinocandins in the treatment and prophylaxis of invasive fungal infections

Invasive fungal infections continue to show steady growth among various patient populations, accompanied by high rates of both morbidity and attributive mortality. For the treatment of invasive mycoses, a few number of drugs are currently available, …

Susceptibility testing of Candida glabrata clinical strains to echinocandins using SensititreTM YeastOneTM system

Objective. To determine susceptibility of C. glabrata isolates to anidulafungin, caspofungin and micafungin using the SensititreTM YeastOneTM system. Materials and Methods. C. glabrata isolates were taken prospectively from clinical specimens or from strains collections in the participating sites. Susceptibility determination was performed using SensititreTM YeastOneTM (YO10 panel) according to the manufacturer’s guidance, and results were interpreted with M27-A3 CLSI guidelines. Susceptibility of C. glabrata to fluconazole was also determined in order to assess possible correlations of echinocandins and fluconazole minimal inhibitory concentrations (MICs) in resistant strains.

Candida glabrata Resistance to Echinocandins Associated with FKS Genes Mutations: How Urgent is the Problem?

The resistance of the systemic Candida infections causative agents is a cornerstone of the selection of an effective therapy. But if before the problem was limited to resistance to azole antifungals, then by now we have enough data about cases of …

Anidulafungin: Brief Clinical Pharmacology Review

Invasive fungal infections are an actual problem of the modern medicine. This is due to the widening population of the affected patients and the increasing number of fungal strains that are resistant to the previously extensively used antifungal …

In Vitro Activity of Fluconazole and Voriconazole Against More Than 10000 Yeast Strains: Results of 5-years Prospective ARTEMIS Disk Study in Russia

Purpose of the study. From 2003 till 2008 eight research centers in Russia from Ekaterinburg, Irkutsk, Krasnodar, Novosibirsk, Moscow, St. Petersburg and Smolensk took part in ARTEMIS Disk study, the main purpose of which was the monitoring of epidemiology of candidiasis causative agents and resistance of the clinically significant Results. A total of 10,652 strains were tested during the period of 5 years. The main sources of clinical material were: genital (36.

Current Options for the Pharmacotherapy of the Invasive Candidiasis in Children

Invasive mycoses are the substantial cause of morbidity and mortality in immunocompromised children. The prevalence of invasive mycoses in this population is around 25% and the mortality rates are run up to 55-60%. Invasive candidiasis is a major …

Management of Patients with Candidiasis: Overview of New IDSA Guidelines

Сandidiasis remains the most frequently occurred form of invasive fungal infections and represents the major part of superficial mycoses. Important factor that contribute to create an accurate guidelines is the increasing number of candidiasis …